Synthesis, characterization and in vivo biological evaluation of novel benzimidazoles as potential anticancer agents


  • Rangaswamy Roopashree
  • Chakrabhavi Dhananjaya Mohan
  • Toreshettahally Ramesh Swaroop
  • Swamy Jagadish
  • KANCHUGARAKOPPAL SUBBEGOWDA RANGAPPA Department of Studies in Chemistry, University of Mysore, Mysore


Objective: Cancer is one of the major cause of death worldwide irrespective of the sex. The aim of the study is to design, synthesize and identification of novel anti-proliferative agents that can potently target cancer.

Methodology: We are reporting the synthesis of new series of N-substituted 2-(2-butyl-4-chloro-1H-imidazole-5-yl)-1H-benzo[d]imidazole derivatives and evaluated for their anti-tumor activity against HeLa cell lines. We identified the lead compound in the series and tested its anti-proliferative and anti-angiogenic properties against EAT bearing mice.

Results: We identified 2-(2-butyl-4-chloro-1-heptyl-1H-imidazol-5yl)-1H-benzo[d]imidazole as a lead compound with the IC50 of 25.3 µM. The lead compound is significantly decreases angiogenesis in peritoneum of EAT bearing mice.

Conclusion: Our results clearly demonstrates that benzimidazoles suppresses the cell proliferation, peritoneal angiogenesis and ascites volume.


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How to Cite

Roopashree, R., C. D. Mohan, T. R. Swaroop, S. Jagadish, and K. S. . RANGAPPA. “Synthesis, Characterization and in Vivo Biological Evaluation of Novel Benzimidazoles As Potential Anticancer Agents”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 309-13,



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