CHITOSAN MICROSPHERES FOR THE DELIVERY OF CHEMOTHERAPEUTIC AGENTS: PACLITAXEL AS A MODEL


Basma Yahya Al-najjar, Saad Abdulrahman Hussain

Abstract


Chitosan has unique physicochemical and biological features that suggest it as a good candidate for the development of safe and effective drug delivery systems. Linking drug molecules with chitosan through a functional spacer enables formulation of prodrugs that have appropriate pharmacological activities at specific desired sites. The development of formulations of targeted delivery systems for the chemotherapeutic agents, especially those with unfavorable pharmacokinetic features, like paclitaxel (PTX), can potentially alleviate the systemic cytotoxicity as well as directing therapy to the specific lesions. The main aim of this literature review is to critically evaluate the use of chitosan microspheres as a drug delivery system to enhance PTX distribution and efficacy in specific targeted sites.


Keywords


Chitosan, Paclitaxel, Microspheres, Drug delivery.

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About this article

Title

CHITOSAN MICROSPHERES FOR THE DELIVERY OF CHEMOTHERAPEUTIC AGENTS: PACLITAXEL AS A MODEL

Keywords

Chitosan, Paclitaxel, Microspheres, Drug delivery.

DOI

10.22159/ajpcr.2017.v10i8.18765

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 15-19

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

74 Views | 101 Downloads

Authors & Affiliations

Basma Yahya Al-najjar
Department of Pharmaceutics, Faculty of Pharmacy, Alrafidain University College, Baghdad, Iraq
Iraq

Saad Abdulrahman Hussain
Department of Pharmaceutics, Faculty of Pharmacy, Alrafidain University College, Baghdad, Iraq
Iraq


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