STUDY THE POTENTIAL ANTIOXIDANT EFFECT OF VITAMIN D3 SUPPLEMENTATION ON THE LEVEL OF EXTRACELLULAR SUPEROXIDE DISMUTASE IN ASTHMATIC PATIENTS

  • Rasha Saadi Abbas Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq.
  • Manal Khalid Abdulridha Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq
  • Mostafa Abdalfatah Shafek Department of Internal Medicine, Al-Yarmouk Teaching Hospital, Baghdad, Iraq.

Abstract

Objective: This study was designed to evaluate the potential antioxidant effect of vitamin D3 supplementation in chronic asthma patients.

Methods: A total of 44 candidate patients were diagnosed with asthma allocated as Group 1 includes 20 patients assigned to receive conventional therapy for asthma and Group 2 includes 24 patients assigned to receive conventional therapy for asthma plus 2000 IU vitamin D3 tablet for 3-month period. Furthermore, 30 apparently healthy subjects were included in the study as a control group. Pulmonary function test, serum 25-hydroxy vitamin D levels, serum extracellular superoxide dismutase (SOD3) levels were measured before and after 3 months therapy.

Results: The mean forced expiratory volume in 1 second (FEV1) both the measured and the percentage of predicted value showed a highly significant increase after 3 months treatment compared to pre-treatment value in both study groups (p<0.01). When compared to pre-treatment value, there was no significant increase in forced expiratory volume in one second to forced vital capacity ratio (FEV1/FVC) in Group 1 (p>0.05), nevertheless, Group 2 showed highly significant increase after 3 months (p<0.01). Approximately, 90-96% of adult asthmatic patients revealed vitamin D deficiency (<20 ng/ml). Post-treatment with adjuvant vitamin D3 therapy, 25% of patients obtained acceptable level of vitamin D sufficiency (≥30 ng/ml). After 3 months of the treatment, Group 1 patients showed a significant decrease in mean SOD3 level compared to pre-treatment level (p<0.05), while Group 2 patients showed a significant increase in mean SOD3 level compared to pre-treatment level (p<0.05).

Conclusion: Most of the asthmatic patients revealed vitamin D deficiency and supplementation with vitamin D3 reduce oxidative stress burden in those patients.

Keywords: Asthma, Pulmonary function test, Vitamin D status, Antioxidant marker.

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Abbas, R. S., M. K. Abdulridha, and M. A. Shafek. “STUDY THE POTENTIAL ANTIOXIDANT EFFECT OF VITAMIN D3 SUPPLEMENTATION ON THE LEVEL OF EXTRACELLULAR SUPEROXIDE DISMUTASE IN ASTHMATIC PATIENTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 7, July 2017, pp. 258-62, doi:10.22159/ajpcr.2017.v10i7.18816.
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