EVALUATION OF PRESCRIBING PATTERN OF FIXED DOSE COMBINATIONS OF ANTIHYPERTENSIVES AND ANTIDIABETIC AGENTS

Niyati D Vyas; Alpa P Gor; Jalpa V Suthar

doi:10.22159/ajpcr.2017.v10i9.18966

Authors

Niyati D Vyas Department of Pharmacy, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology Campus-Changa, Gujarat,India.
Alpa P Gor Department of Pharmacology, Pramukhswami Medical College, Karamsad, Gujarat, India.
Jalpa V Suthar Department of Clinical Pharmacy, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology Campus-Changa, Gujarat, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i9.18966

Keywords:

Fixed dose combinations, Antihypertensives, Antidiabetics

Abstract

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Â Objective: The objective of this research was to evaluate prescribing pattern of fixed dose combinations (FDCs) of antihypertensives and antidiabetic agents among patients of private hospitals.

Methods: An observational study was carried out in the outpatient department of two hospitals. Data of patients being diagnosed with the symptoms of hypertension and diabetes were enrolled which mainly included information related to prescribe FDCs, i.e., antihypertensives and antidiabetics, respectively. Descriptive analysis of collected information was done which involved representation of demographical data, number of comorbidities, number of FDCs prescribed, and type of FDCs consequently.

Results: Combination drug therapy was prescribed in maximum patients, which was enumerated as 93% among hypertensive patients and about 91% in diabetics. Average age of patients suffering more from hypertension was 64.5Â±18 years and that in case of diabetes sufferers was 54.5Â±18 years. The most frequent combination prescribed in hypertensive patients was of angiotensin receptor blocker (ARB) and calcium channel blocker (CCB) which were about 53%, and in diabetic patients, it was of biguanides and sulfonylureas about 63%. Comorbidity too was notified, and its estimation was 61% in hypertensive patients and 72% in diabetic patients, respectively.

Conclusion: The study here demonstrates that the most often prescribed antihypertensive combination is of ARB and CCB, and subsequently for diabetes, the oral hypoglycemic combination is of biguanides and sulfonylureas. Most of FDCs contained medications of these two classes. Positive results were also observed in levels of blood pressure and glucose within the normal range.

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