PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF CALLISTEMON CITRINUS FOR ANTIDEPRESSANT ACTIVITY IN ALBINO MICE


Vijetha Pendyala, Santhrani Thaakur

Abstract


Objective: The present study was carried out to find out the antidepressant activity of different fractions of stems and leaves of Callistemon citrinus(CC). The efficacy of the fractions was compared with the standard reference drug imipramine.

Methods: All the studies were conducted according to the ethical guidelines of CPCSEA. Healthy adult albino mice weighing 20-30 g were used asexperimental animals. The leaves of CC were extracted with alcohol and fractionated with chloroform and petroleum ether. All the fractions weresubjected for preliminary phytochemical screening, using various qualitative tests. In the present investigation, tail suspension test (TST) and forcedswim test (FST) are selected as animal models for evaluation of antidepressant activity in albino mice.

Results: The preliminary phytochemical screening of CC has revealed the presence of carbohydrates, tannins, and flavonoids in a hydroalcoholicfraction. Chloroform fraction showed positive results toward flavonoids, alkaloids, tannins, glycosides, and steroids. Alcoholic and chloroform extract(100 and 200 mg/kg p.o.) of CC administered orally for 14 successive days had decreased the immobility periods significantly in a dose-dependentmanner in both TST and FST, showing significant antidepressant-like activity. The activities of the extracts were found to be comparable to imipraminein both FST and TST.

Conclusions: Although a number of synthetic drugs are being used as a standard treatment for clinically depressed patient, they have adverseeffects that can compromise the therapeutic treatment. In the traditional systems of medicine, many plants and formulations have been used to treatdepression for thousands of years. The results of the study indicate that CC can be used as an antidepressant herb.


Keywords


Callistemon citrinus, Antidepressant activity, Forced swim test, Tail suspension test, Depression.

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About this article

Title

PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF CALLISTEMON CITRINUS FOR ANTIDEPRESSANT ACTIVITY IN ALBINO MICE

Keywords

Callistemon citrinus, Antidepressant activity, Forced swim test, Tail suspension test, Depression.

DOI

10.22159/ajpcr.2017.v10i8.18998

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 232-234

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

106 Views | 92 Downloads

Authors & Affiliations

Vijetha Pendyala
Department of Pharmacognosy, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India
India

Santhrani Thaakur
Departmet of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupati, Andhra Pradesh, India.
India


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