ANTI-ELASTASE, ANTI-COLLAGENASE AND ANTIMICROBIAL ACTIVITIES OF THE UNDERUTILIZED RED PITAYA PEEL: AN IN VITRO STUDY FOR ANTI-AGING APPLICATIONS


Ramya Vijayakumar, Siti Salwa Abd Gani, Nor Fadzillah Mohd Mokhtar

Abstract


 

 Objective: To investigate the in vitro anti-elastase, anti-collagenase, and antimicrobial activities of the red pitaya peel extract for cosmetic application focusing on skin aging.

Methods: Extraction was performed by the reflux method for 103 minutes at 56°C with 82% aqueous ethanol solution and the red pitaya peel extract was evaporated using a rotary evaporator. Anti-elastase and anti-collagenase properties were evaluated using the drug discovery kits (neutrophil elastase colorimetric and matrix metalloproteinase-1 colorimetric, respectively). The antimicrobial potential was analyzed using agar well diffusion method against 10 selected microorganisms, and the presence or absence of the inhibition zones was identified.

Results: The red pitaya peel extract exhibited remarkable inhibition percentage 87.62±0.05% and 96.92±0.02% for anti-elastase and anti-collagenase activities, respectively. Red pitaya peel extract showed significant inhibition against the Gram-positive Bacillus subtilis B29 with an inhibition zone diameter of 8.0±0.3 mm.

Conclusion: The excellent anti-aging properties displayed by the underutilized red pitaya peel extract highlighted its potential as a natural source of anti-aging agent for cosmetic formulations.


Keywords


Skin aging, Anti-elastase, Anti-collagenase, Antimicrobial, Red pitaya peel.

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About this article

Title

ANTI-ELASTASE, ANTI-COLLAGENASE AND ANTIMICROBIAL ACTIVITIES OF THE UNDERUTILIZED RED PITAYA PEEL: AN IN VITRO STUDY FOR ANTI-AGING APPLICATIONS

Keywords

Skin aging, Anti-elastase, Anti-collagenase, Antimicrobial, Red pitaya peel.

DOI

10.22159/ajpcr.2017.v10i8.19048

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 251-255

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

247 Views | 300 Downloads

Authors & Affiliations

Ramya Vijayakumar
Institut Penyelidikan Produk Halal, University Putra Malaysia, Putra Infoport, 43400 UPM Serdang, Selangor, Malaysia
Malaysia

Siti Salwa Abd Gani
Lapsah, IPPH, Universiti Putra Malaysia, Putra Infoport, 43400 UPM Serdang, Selangor, Malaysia.
Malaysia

Nor Fadzillah Mohd Mokhtar
Lapsah, IPPH, Universiti Putra Malaysia, Putra Infoport, 43400 UPM Serdang, Selangor, Malaysia.
Malaysia


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