DEVELOPMENT AND EVALUATION OF ANTI-ACNE GEL CONTAINING GARLIC (ALLIUM SATIVUM) AGAINST PROPIONIBACTERIUM ACNES


Nyi Mekar Saptarini, Irma Erika Herawati

Abstract


Objective: The aim of this study is to develop and evaluate the gel of garlic juice as anti-acne to facilitate the topical usage.

Methods: The steps of this study consisted of extraction, gel formulations with various concentrations of carboxymethyl cellulose (CMC), and gel evaluation, i.e., organoleptic, viscosity, pH, skin irritation test, hedonic test, and anti-acne activity assay against Propionibacterium acnes.

Results: The garlic juice contains alkaloids, saponins, tannins, monoterpenes, and sesquiterpenes. The different concentrations of CMC produce different physicochemistry properties of the gels. These properties were affected the gels stability, anti-acne activity, and the panelis perception on hedonic test.

Conclusion: The garlic juice at 7.5% has anti-acne activity to P. acnes, and the gel of 3% CMC is the most stable and preferable.


Keywords


Garlic juice, Carboxymethyl cellulose, Gel evaluation, Propionibacterium acnes.

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About this article

Title

DEVELOPMENT AND EVALUATION OF ANTI-ACNE GEL CONTAINING GARLIC (ALLIUM SATIVUM) AGAINST PROPIONIBACTERIUM ACNES

Keywords

Garlic juice, Carboxymethyl cellulose, Gel evaluation, Propionibacterium acnes.

DOI

10.22159/ajpcr.2017.v10i8.19271

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 260-262

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

78 Views | 102 Downloads

Authors & Affiliations

Nyi Mekar Saptarini
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Jl Raya Bandung Sumedang Km 21, West Java, Indonesia.
Indonesia

Irma Erika Herawati
Departement of Pharmacy, Faculty of Math and Natural Science, University of Al Ghifari, Jl Cisaranten Kulon 140, West Java, Indonesia
Indonesia


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