SUPPLEMENTATION OF VITAMIN E 400 IU DECREASES MALONDIALDEHYDE LEVEL OF OBESE WOMEN STAFF AT SCHOOL OF MEDICINE UDAYANA UNIVERSITY


Luh Putu Ratna Sundari, Nyoman Adiputra, Made Krisna Dinata

Abstract


 

 Objective: Increasing of adipose tissue in obesity make an inflammation cellular due to stress oxidative. Malondialdehyde (MDA) is produced by that cellular reaction and used as indicator peroxidation lipid reaction in many tissues. Vitamin E will inhibit lipid peroxidation reaction. This study is about the effectiveness of vitamin E to decrease the MDA level in obesity women.

Methods: The pre- and post-test control group design study was conducted on 24 female obese women. Subjects were divided into two groups randomly with 12 women each group. Control group was given placebo capsules, and the experimental group was given vitamin E capsules 400 IU for 30 days. MDA level was measured before and after treatment, analyzed by independent t-test and the p<0.05 was considered significant.

Results: The decreasing of MDA level of the control group was 1.601±0.313 μmol/ml, and experimental group was 2.161±0.471 μmol/ml. From post-test result comparison, the experimental group shows a significant decrease (p<0.05) of MDA level.

Conclusion: Vitamin E supplementation can decrease MDA level in obese women staff at School of Medicine Udayana University.


Keywords


Vitamin E, Lipid peroxide, Malondialdehyde, Obesity.

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About this article

Title

SUPPLEMENTATION OF VITAMIN E 400 IU DECREASES MALONDIALDEHYDE LEVEL OF OBESE WOMEN STAFF AT SCHOOL OF MEDICINE UDAYANA UNIVERSITY

Keywords

Vitamin E, Lipid peroxide, Malondialdehyde, Obesity.

DOI

10.22159/ajpcr.2017.v10i9.19400

Date

01-09-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 9 September 2017 Page: 61-63

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Luh Putu Ratna Sundari
Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia
Indonesia

Nyoman Adiputra
Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia
Indonesia

Made Krisna Dinata
Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia
Indonesia


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