SUPPLEMENTATION OF VITAMIN E 400 IU DECREASES MALONDIALDEHYDE LEVEL OF OBESE WOMEN STAFF AT SCHOOL OF MEDICINE UDAYANA UNIVERSITY
Â Objective: Increasing of adipose tissue in obesity make an inflammation cellular due to stress oxidative. Malondialdehyde (MDA) is produced by that cellular reaction and used as indicator peroxidation lipid reaction in many tissues. Vitamin E will inhibit lipid peroxidation reaction. This study is about the effectiveness of vitamin E to decrease the MDA level in obesity women.
Methods: The pre- and post-test control group design study was conducted on 24 female obese women. Subjects were divided into two groups randomly with 12 women each group. Control group was given placebo capsules, and the experimental group was given vitamin E capsules 400 IU for 30 days. MDA level was measured before and after treatment, analyzed by independent t-test and the p<0.05 was considered significant.
Results: The decreasing of MDA level of the control group was 1.601Â±0.313 Î¼mol/ml, and experimental group was 2.161Â±0.471 Î¼mol/ml. From post-test result comparison, the experimental group shows a significant decrease (p<0.05) of MDA level.
Conclusion: Vitamin E supplementation can decrease MDA level in obese women staff at School of Medicine Udayana University.
2. Bollapragada MK, Shantaram M, Kumar S. Obesity: Development, epidemiology, factors affecting, quantity, health hazards, management and natural treatment-a review. Int J Pharm Pharm Sci 2017;9(2):12-26.
3. Dixon JB. The effect of obesity on health outcomes. Mol Cell Endocrinol 2010;316:104-8.
4. Cancello R, ClÃ©ment K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 2006;113(10):1141-7.
5. Kale MA, Bindu SM, Khadkikar P. Role of antioxidants and nutrition in oxidative stress: A review. Int J Appl Pharm 2015;7(1):1-4.
6. Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean? Br J Pharmacol 2004;142(2):231-55.
7. Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, et al. Antioxidant vitamin supplements and cardiovascular disease. Circulation 2004;110(5):637-41.
8. Packer L. Protective role of vitamin E in biological systems. Am J Clin Nutr 1991;53 4 Suppl:1050S-5.
9. Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 2006;30(3):400-18.
10. Vincent HK, Bourguignon C, Taylor AG. Relationship between the newly proposed dietary phytochemical index, obesity and oxidative stress in young healthy adults. J Hum Nutr Diet 2010;23(1):20-9.
11. Aydin B. The effects of capsaicin and vitamin E on high fat diet induced obesity, hyperlipidemia and oxidative stress in different organs of mice. J Food Nutr Res 2015;3(6):357-64.
12. Viroonudomphol D, Pongpaew P, Tungtrongchitr R, Changbumrung S, Tungtrongchitr A, Phonrat B, et al. The relationships between anthropometric measurements, serum vitamin A and E concentrations and lipid profiles in overweight and obese subjects. Asia Pac J Clin Nutr 2003;12(1):73-9.
13. Sukantha TA, Sripathi SK, Ravindran NT, Balashanmugam P. Antioxidant and antibacterial activities of Trianthema decandra Linn. Int J Pharm Pharm Sci 2012;4:410-3.
14. Singh K, Singh S. Comparative study on malondialdehyde and certain antioxidants in North West obese Indians. J Cardiovasc Dis Res 2015;6(3):138-44.
15. Devaraj S, Tang R, Adams-Huet B, Harris A, Seenivasan T, de Lemos JA, et al. Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr 2007;86(5):1392-8.
16. AlcalÃ¡ M, SÃ¡nchez-Vera I, Sevillano J, Herrero L, Serra D, Ramos MP, et al. Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity. Obesity (Silver Spring) 2015;23(8):1598-606.