SUPPLEMENTATION OF VITAMIN E 400 IU DECREASES MALONDIALDEHYDE LEVEL OF OBESE WOMEN STAFF AT SCHOOL OF MEDICINE UDAYANA UNIVERSITY

  • Luh Putu Ratna Sundari Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia
  • Nyoman Adiputra Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia
  • Made Krisna Dinata Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia

Abstract

 

 Objective: Increasing of adipose tissue in obesity make an inflammation cellular due to stress oxidative. Malondialdehyde (MDA) is produced by that cellular reaction and used as indicator peroxidation lipid reaction in many tissues. Vitamin E will inhibit lipid peroxidation reaction. This study is about the effectiveness of vitamin E to decrease the MDA level in obesity women.

Methods: The pre- and post-test control group design study was conducted on 24 female obese women. Subjects were divided into two groups randomly with 12 women each group. Control group was given placebo capsules, and the experimental group was given vitamin E capsules 400 IU for 30 days. MDA level was measured before and after treatment, analyzed by independent t-test and the p<0.05 was considered significant.

Results: The decreasing of MDA level of the control group was 1.601±0.313 μmol/ml, and experimental group was 2.161±0.471 μmol/ml. From post-test result comparison, the experimental group shows a significant decrease (p<0.05) of MDA level.

Conclusion: Vitamin E supplementation can decrease MDA level in obese women staff at School of Medicine Udayana University.

Keywords: Vitamin E, Lipid peroxide, Malondialdehyde, Obesity.

Author Biographies

Luh Putu Ratna Sundari, Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia
Physiology Department
Nyoman Adiputra, Department of Physiology, School of Medicine, Udayana University, Bali, Indonesia
Physiology Department

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How to Cite
Sundari, L. P., N. Adiputra, and M. Dinata. “SUPPLEMENTATION OF VITAMIN E 400 IU DECREASES MALONDIALDEHYDE LEVEL OF OBESE WOMEN STAFF AT SCHOOL OF MEDICINE UDAYANA UNIVERSITY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 9, Sept. 2017, pp. 61-63, doi:10.22159/ajpcr.2017.v10i9.19400.
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