• Judy Perez Department of Chemistry, De La Salle University, Manila, Philippines. Department of Natural Sciences, College of Science and Engineering, Ateneo de Naga University, Camarines Sur, Philippines.
  • Chien-chang Shen Division of Chinese Medicinal Chemistry, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taiwan.
  • Consolacion Y Ragasa Department of Chemistry, De La Salle University Science & Technology Complex Leandro V. Locsin Campus, Philippines



Ceriops decandra, Rhizophoraceae, Nil, Lupeol fatty acid esters, Betulonic acid, Betulin, Betulinic acid, Lupeol, Lupenone, Nil, Nil



 Objective: To isolate and identify the chemical constituents of Ceriops decandra.

Methods: The chemical constituents of C. decandra (Griff.) W. Theob. were isolated by silica gel chromatography. The structures of the isolated compounds were identified by nuclear magnetic resonance (NMR) spectroscopy.

Results: Chemical investigation of the dichloromethane extracts of the leaves of C. decandra has led to the isolation of 3β-E-coumaroylbetulinic acid (1), lupeol fatty acid esters (2), betulonic acid (3), betulin (4), betulinic acid (5), lupeol (6), lupenone (7), and a mixture of 3β-E-feruloyllupeol (8) and 3β-Z-feruloyllupeol (9), and chlorophyll a (10). The structures of 1-10 were identified by comparison of their NMR data with literature data.

Conclusion: To the best of our knowledge, this is the first report on the isolation of 1-3 from C. decandra. Literature search revealed that the triterpenes isolated from C. decandra exhibited anticancer properties.


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Author Biography

Judy Perez, Department of Chemistry, De La Salle University, Manila, Philippines. Department of Natural Sciences, College of Science and Engineering, Ateneo de Naga University, Camarines Sur, Philippines.

Chemistry Department, De La Salle University

Full Professor 10


Ceriops Decandra (PROSEA). Plant Use. Downloaded Fromuses. Available from: (PROSEA). [Last accessed on 2017 Apr 22].

Revathi P, Senthinath JJ, Thirumalaikolundusubramanian P, Prabhu N. An overview of antidiabetic profile of mangrove plants. Int J Pharm Pharm Sci 2014;6(3):1-5.

Salini G. Pharmacological profile of mangrove endophytes-a review. Int J Pharm Pharm Sci 2015;7(1):6-15.

Ponlimangini C, Thongdeeying P. Lupane-triterpene esters from the leaves of Ceriops decandra (Griff.) Ding Hou. Aust J Chem 2005;58:615-8.

Ghosh A, Misra S, Dutta AK, Choudhury A. Pentacyclic triterpenoids and sterols from seven species of mangrove. Phytochemestry 1985;24:1725-7.

Wang H, Li MY, Satyanandamurty T, Wu J. New diterpenes from a Godavari mangrove, Ceriops decandra. Planta Med 2013;79(8):666-72.

Thongdeeying P, Chantrapromma S, Fun HK, Anjum S, Ali S, Ponglimanont C. 2-(9-Hydroxy-3a,5a,5b,8,8,11a-hexamethylicosahydro-1H-cyclopenta[a]chrysen-1-yl)propanoic acid (3[beta]- hydroxylupan-29-oic acid). Acta Crystallogr Sec E Struct Rep Online 2005;61:1861-3.

Seshadri TR, Trikha RK. Procyanidins of Ceriops roxburghiana and Rhizophora conjugata. Indian J Chem 1971;9:928-30.

Wang H, Li MY, Katele FZ, Satyanandamurty T, Wu J, Bringmann G. Decandrinin, an unprecedented C9-spiro-fused 7,8-seco-ent-abietane from the Godavari mangrove Ceriops decandra. Beilstein J Org Chem 2014;10:276-81.

Wang H, Zou K, Wu J. Chemical constituents of barks of Ceriops decandra. Huazhong Shifan Daxue Xuebao Ziran Kexueban 2013;47:794-6.

Wang H, Wu J. Diterpenoids from barks Ceriops decandra. Zhongcaoyao 2013;44:532-6.

Simlai A, Mukherjee K, Mandal A, Bhattacharya K, Samanta A, Roy A. Partial purification and characterization of an antimicrobial activity from the wood extract of mangrove plant Ceriops decandra. EXCLI J 2016;15:103-12.

Anjaneyulu AS, Rao VL. Ceriopsins A-D, diterpenoids from Ceriops decandra. Phytochemistry 2002;60(8):777-82.

Anjaneyulu AS, Rao VL, Lobkovsky E, Clardy J. Ceriopsin E, a new epoxy ent-kaurene diterpenoid from Ceriops decandra. J Nat Prod 2002;65(4):592-4.

Anjaneyulu AS, Rao VL. Ceriopsins F and G, diterpenoids from Ceriops decandra. Phytochemistry 2003;62(8):1207-11.

Ragasa CY, Ebajo VD Jr, de Los Reyes MM, Mandia EH, BrkljaÄa R, Urban S. Triterpenes and sterols from Sonneratia alba. Int J Curr Pharm Rev Res 2014;6:256-61.

Rashid MA, Gray AI, Waterman PG, Armstrong JA. Coumarins from Phebalium tuberculosum ssp. Megaphyllum and Phebalium filifolium. J Nat Prod 1992;55(7):851-8.

Mallavadhani UV, Mahapatra A, Jamil K, Reddy PS. Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chains. Biol Pharm Bull 2004;27(10):1576-9.

Haavikko R, Nasereddin A, Sacerdoti-Sierra N, Kopelyanskiy D, Alakurtti S, Tikka M, et al. Heterocycle-fused lupane triterpenoids inhibit Leishmania donovani amastigotes. Med Chem Commun 2014;5:445-51.

Ragasa CY, Lim F, Raga DD, Shen CC. Hypoglycemic potential of triterpenes from Alstonia scholaris. Pharm Chem J 2013;47:54-8.

Khaliq S, Volk FJ, Frahm AW. Phytochemical investigation of Perovskia abrotanoides. Planta Med 2007;73(1):77-83.

Prakash CV, Prakash I. Isolation and structural characterization of lupane triterpenes from Polypodium vulgare. Res J Pharm Sci 2012;1:23-7.

Ragasa CY, de Jesus J. Porphyrins and polyprenols from Macaranga tanarius. Res J Pharm Biol Chem Sci 2014;5:701-8.

Wada S, Tanaka R. Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica. Chem Biodivers 2005;2:689-94.

Fulda S. Betulinic acid: A natural product with anticancer activity. Mol Nutr Food Res 2009;53(1):140-6.

Tripathi L, Kumar P, Singh R. A review on extraction, synthesis and anticancer activity of betulinic acid. Curr Bioact Compd 2009;5:160-8.

Moghaddam MG, Ahmad FB, Samzadeh-Kermani A. Biological activity of betulinic acid: A review. Pharmacol Pharm 2012;3:119-23.

Lee SY, Kim HH, Park SU. Recent studies on betulinic acid and its biological and pharmacological activity. EXCLI J 2015;14:199-203.

Periasamy G, Teketelew G, Gebrelibanos M, Sintayehu B, Gebrehiwot M, Karim A, et al. Betulinic acid and its derivatives as anti-cancer agent: A review. Arch Appl Sci Res 2014;6:47-58.

Yogeeswari P, Sriram D. Betulinic acid and its derivatives: A review on their biological properties. Curr Med Chem 2005;12(6):657-66.

Król SK, Kielbus M, Rivero-Müller A, Stepulak A. Comprehensive review on betulin as a potent anticancer agent. Biomed Res Int 2015;2015:584189.



How to Cite

Perez, J., C.- chang Shen, and C. Y. Ragasa. “ THEOB”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 11, Nov. 2017, pp. 244-6, doi:10.22159/ajpcr.2017.v10i11.19461.



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