Judy Perez, Chien-chang Shen, Consolacion Y Ragasa



 Objective: To isolate and identify the chemical constituents of Ceriops decandra.

Methods: The chemical constituents of C. decandra (Griff.) W. Theob. were isolated by silica gel chromatography. The structures of the isolated compounds were identified by nuclear magnetic resonance (NMR) spectroscopy.

Results: Chemical investigation of the dichloromethane extracts of the leaves of C. decandra has led to the isolation of 3β-E-coumaroylbetulinic acid (1), lupeol fatty acid esters (2), betulonic acid (3), betulin (4), betulinic acid (5), lupeol (6), lupenone (7), and a mixture of 3β-E-feruloyllupeol (8) and 3β-Z-feruloyllupeol (9), and chlorophyll a (10). The structures of 1-10 were identified by comparison of their NMR data with literature data.

Conclusion: To the best of our knowledge, this is the first report on the isolation of 1-3 from C. decandra. Literature search revealed that the triterpenes isolated from C. decandra exhibited anticancer properties.


Ceriops decandra, Rhizophoraceae, 3β-E-coumaroylbetulinic acid, Lupeol fatty acid esters, Betulonic acid, Betulin, Betulinic acid, Lupeol, Lupenone, 3β-E-feruloyllupeol, 3β-Z-feruloyllupeol.

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Ceriops Decandra (PROSEA). Plant Use. Downloaded Fromuses. Available from: (PROSEA). [Last accessed on 2017 Apr 22].

Revathi P, Senthinath JJ, Thirumalaikolundusubramanian P, Prabhu N. An overview of antidiabetic profile of mangrove plants. Int J Pharm Pharm Sci 2014;6(3):1-5.

Salini G. Pharmacological profile of mangrove endophytes-a review. Int J Pharm Pharm Sci 2015;7(1):6-15.

Ponlimangini C, Thongdeeying P. Lupane-triterpene esters from the leaves of Ceriops decandra (Griff.) Ding Hou. Aust J Chem 2005;58:615-8.

Ghosh A, Misra S, Dutta AK, Choudhury A. Pentacyclic triterpenoids and sterols from seven species of mangrove. Phytochemestry 1985;24:1725-7.

Wang H, Li MY, Satyanandamurty T, Wu J. New diterpenes from a Godavari mangrove, Ceriops decandra. Planta Med 2013;79(8):666-72.

Thongdeeying P, Chantrapromma S, Fun HK, Anjum S, Ali S, Ponglimanont C. 2-(9-Hydroxy-3a,5a,5b,8,8,11a-hexamethylicosahydro-1H-cyclopenta[a]chrysen-1-yl)propanoic acid (3[beta]- hydroxylupan-29-oic acid). Acta Crystallogr Sec E Struct Rep Online 2005;61:1861-3.

Seshadri TR, Trikha RK. Procyanidins of Ceriops roxburghiana and Rhizophora conjugata. Indian J Chem 1971;9:928-30.

Wang H, Li MY, Katele FZ, Satyanandamurty T, Wu J, Bringmann G. Decandrinin, an unprecedented C9-spiro-fused 7,8-seco-ent-abietane from the Godavari mangrove Ceriops decandra. Beilstein J Org Chem 2014;10:276-81.

Wang H, Zou K, Wu J. Chemical constituents of barks of Ceriops decandra. Huazhong Shifan Daxue Xuebao Ziran Kexueban 2013;47:794-6.

Wang H, Wu J. Diterpenoids from barks Ceriops decandra. Zhongcaoyao 2013;44:532-6.

Simlai A, Mukherjee K, Mandal A, Bhattacharya K, Samanta A, Roy A. Partial purification and characterization of an antimicrobial activity from the wood extract of mangrove plant Ceriops decandra. EXCLI J 2016;15:103-12.

Anjaneyulu AS, Rao VL. Ceriopsins A-D, diterpenoids from Ceriops decandra. Phytochemistry 2002;60(8):777-82.

Anjaneyulu AS, Rao VL, Lobkovsky E, Clardy J. Ceriopsin E, a new epoxy ent-kaurene diterpenoid from Ceriops decandra. J Nat Prod 2002;65(4):592-4.

Anjaneyulu AS, Rao VL. Ceriopsins F and G, diterpenoids from Ceriops decandra. Phytochemistry 2003;62(8):1207-11.

Ragasa CY, Ebajo VD Jr, de Los Reyes MM, Mandia EH, Brkljača R, Urban S. Triterpenes and sterols from Sonneratia alba. Int J Curr Pharm Rev Res 2014;6:256-61.

Rashid MA, Gray AI, Waterman PG, Armstrong JA. Coumarins from Phebalium tuberculosum ssp. Megaphyllum and Phebalium filifolium. J Nat Prod 1992;55(7):851-8.

Mallavadhani UV, Mahapatra A, Jamil K, Reddy PS. Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chains. Biol Pharm Bull 2004;27(10):1576-9.

Haavikko R, Nasereddin A, Sacerdoti-Sierra N, Kopelyanskiy D, Alakurtti S, Tikka M, et al. Heterocycle-fused lupane triterpenoids inhibit Leishmania donovani amastigotes. Med Chem Commun 2014;5:445-51.

Ragasa CY, Lim F, Raga DD, Shen CC. Hypoglycemic potential of triterpenes from Alstonia scholaris. Pharm Chem J 2013;47:54-8.

Khaliq S, Volk FJ, Frahm AW. Phytochemical investigation of Perovskia abrotanoides. Planta Med 2007;73(1):77-83.

Prakash CV, Prakash I. Isolation and structural characterization of lupane triterpenes from Polypodium vulgare. Res J Pharm Sci 2012;1:23-7.

Ragasa CY, de Jesus J. Porphyrins and polyprenols from Macaranga tanarius. Res J Pharm Biol Chem Sci 2014;5:701-8.

Wada S, Tanaka R. Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica. Chem Biodivers 2005;2:689-94.

Fulda S. Betulinic acid: A natural product with anticancer activity. Mol Nutr Food Res 2009;53(1):140-6.

Tripathi L, Kumar P, Singh R. A review on extraction, synthesis and anticancer activity of betulinic acid. Curr Bioact Compd 2009;5:160-8.

Moghaddam MG, Ahmad FB, Samzadeh-Kermani A. Biological activity of betulinic acid: A review. Pharmacol Pharm 2012;3:119-23.

Lee SY, Kim HH, Park SU. Recent studies on betulinic acid and its biological and pharmacological activity. EXCLI J 2015;14:199-203.

Periasamy G, Teketelew G, Gebrelibanos M, Sintayehu B, Gebrehiwot M, Karim A, et al. Betulinic acid and its derivatives as anti-cancer agent: A review. Arch Appl Sci Res 2014;6:47-58.

Yogeeswari P, Sriram D. Betulinic acid and its derivatives: A review on their biological properties. Curr Med Chem 2005;12(6):657-66.

Król SK, Kielbus M, Rivero-Müller A, Stepulak A. Comprehensive review on betulin as a potent anticancer agent. Biomed Res Int 2015;2015:584189.

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Ceriops decandra, Rhizophoraceae, 3β-E-coumaroylbetulinic acid, Lupeol fatty acid esters, Betulonic acid, Betulin, Betulinic acid, Lupeol, Lupenone, 3β-E-feruloyllupeol, 3β-Z-feruloyllupeol.





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Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 11 November 2017 Page: 244-246

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Authors & Affiliations

Judy Perez
Department of Chemistry, De La Salle University, Manila, Philippines. Department of Natural Sciences, College of Science and Engineering, Ateneo de Naga University, Camarines Sur, Philippines.

Chien-chang Shen
Division of Chinese Medicinal Chemistry, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taiwan.
Taiwan, Republic of China

Consolacion Y Ragasa
Department of Chemistry, De La Salle University Science & Technology Complex Leandro V. Locsin Campus, Philippines

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