ANTI-ATHEROSCLEROTIC ACTIVITY OF ETHANOLIC EXTRACT OF CHRYSANTHEMUM INDICUM L. FLOWERS AGAINST HIGH-FAT DIET-INDUCED ATHEROSCLEROSIS IN MALE WISTAR RATS


Sravanthi P, Shakir Basha S

Abstract


 

 Objective: The aim of the present study was to evaluate the anti-atherosclerotic activity of ethanolic extract of Chrysanthemum indicum (EECI) flowers against high-fat diet induction in male Wistar rats.

Methods: The method used for induction of atherosclerosis was high-fat diet for 28 days. Rats were divided into five groups (n=6). Group I served as normal. Group II serves as high-fat diet-treated group. Group III serves as standard treated with high-fat diet+atorvastatin (30 mg/kg, p.o). Group IV serves as low dose treated with high-fat diet+EECI (150 mg/kg, p.o.). Group V serves as high dose treated with high-fat diet+EECI (300 mg/kg, p.o.). The following parameters, glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), very LDL (VLDL), triglycerides (TG), atherogenic index (AI), serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, total protein, food consumption, and body weight, were evaluated and histopathological studies were performed.

Results: The results showed that EECI at a dose of 150 mg/kg and 300 mg/kg exhibited significant decrease in glucose, TG, TC, LDL-cholesterol (LDL-C), HDL, VLDL, AI, and total protein levels when compared to high-fat diet group. This investigation reveals that the extract-treated groups lower the serum TC and LDL-C levels significantly, which reduces the risk of coronary heart disease.

Conclusion: The experimental studies show that the EECI of both doses 150 mg/kg and 300 mg/kg, respectively, showed significant reduction in lipid profile, glucose, and total protein. From the study, the plant extract showed anti-atherosclerotic activity and thus authenticates its ethnomedicinal use.

 


Keywords


Atherosclerosis, Atherogenic diet, Chrysanthemum indicum L., Atorvastatin.

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About this article

Title

ANTI-ATHEROSCLEROTIC ACTIVITY OF ETHANOLIC EXTRACT OF CHRYSANTHEMUM INDICUM L. FLOWERS AGAINST HIGH-FAT DIET-INDUCED ATHEROSCLEROSIS IN MALE WISTAR RATS

Keywords

Atherosclerosis, Atherogenic diet, Chrysanthemum indicum L., Atorvastatin.

DOI

10.22159/ajpcr.2017.v10i9.19463

Date

01-09-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 9 September 2017 Page: 52-56

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Sravanthi P
Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati - 517 102, Andhra Pradesh, India.
India

Shakir Basha S
Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati - 517 102, Andhra Pradesh, India.
India


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