G-QUADRUPLEX LIGANDS AS STABILIZER TARGETING TELOMERASE ENZYME AS ANTI CANCER AGENTS


Hemalatha Cn, Vijey Aanandhi M, Vijey Aanandhi M

Abstract


The human telomere stabilization with G-Quadruplex DNA tends to induce apoptosis. The molecular target of telomere cascade with a rigid molecular may show efficacious to treat cancer. The study of intercalation to human telomeric DNA with proposed ligand can be evaluated by the help of biophysical studies and biological studies. G-Quadruplex is one of the key epigenetic episodes of eukaryotes and prokaryotes, generally found in the telomeric end region, immunoglobulin switch recombination and the lagging strand of the DNA. These chemotherapeutic advances are not enough to maintain a life expectancy of cancer affected patients. A number of G-Quadruplex ligands such as acridine, perylene, and anthraquinones have been synthesized reported and evaluated them for the inhibitor activity. Therefore, translational research can pave the novel prospect to treat cancer in a fundamental way. In that connection, basic research showed G-Quadruplex phenomenon of DNA, which is having a great impact in this chemotherapy.


Keywords


Perylene derivatives, G-Quadruplex, Telomerase, Anticancer.

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About this article

Title

G-QUADRUPLEX LIGANDS AS STABILIZER TARGETING TELOMERASE ENZYME AS ANTI CANCER AGENTS

Keywords

Perylene derivatives, G-Quadruplex, Telomerase, Anticancer.

DOI

10.22159/ajpcr.2017.v10i8.19797

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 50-53

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

90 Views | 136 Downloads

Authors & Affiliations

Hemalatha Cn
Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.
India

Vijey Aanandhi M
Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.
India

Vijey Aanandhi M
Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.
India


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