HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CHEBULA FRUIT AGAINST ETHANOL INDUCED HEPATOTOXICITY IN RATS


Balakrishna Vuyyala, Lakshmi Thakkalapally

Abstract


 

 Objective: The purpose of this study was to evaluate the effect of Terminalia chebula fruit extract on liver antioxidant enzymes in ethanol-induced hepatotoxicity in rats.

Method: Rats were divided into six different groups each having six. Group 1 served as a control, Group 2 received 40% ethanol (2 ml/100 g, oral), in sterile water, Groups 4, 5, and 6 served as extract treatment groups and received 50, 100, and 200 mg/kg, orally, ethanolic fruit extract of T. chebula (TCE) and Group 3 served as standard group and received silymarin 25 mg/kg orally. All the treatment protocols followed 21 days, and after which rats were sacrificed, the liver was taken for antioxidant and histological studies, respectively.

Results: The ethanol-treated group rats (G2) showed variable decrease in antioxidant parameter (catalase, glutathione, and glutathione reductase) levels. Administration of ethanolic TCE significantly prevented ethanol-induced elevation in the levels of malondialdehyde lipid peroxidation and decreased antioxidant parameters in experimental groups of rats. The effect of extract was compared with a standard drug, silymarin. The changes in antioxidant parameters were supported by histological profile.

Conclusion: It is concluded that the ethanolic fruit TCE protects against ethanol-induced oxidative liver injury in rats.


Keywords


Terminalia chebula, Ethanol, Hepatotoxicity, Silymarin, Extract of Terminalia chebula.

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About this article

Title

HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CHEBULA FRUIT AGAINST ETHANOL INDUCED HEPATOTOXICITY IN RATS

Topics

Asst. Professor, Department of pharmacology, GNITC-School of pharmacy, Ibrahimpatnam, Hyderabad

Keywords

Terminalia chebula, Ethanol, Hepatotoxicity, Silymarin, Extract of Terminalia chebula.

DOI

10.22159/ajpcr.2017.v10i11.20270

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 11 November 2017 Page: 55-58

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

32 Views | 69 Downloads

Authors & Affiliations

Balakrishna Vuyyala
Department of Pharmacology, Guru Nanak Institutions Technical Campus, School of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana, India.
India

Lakshmi Thakkalapally
Department of Pharmacology, Guru Nanak Institutions Technical Campus, School of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana, India.
India


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