OKRA FRUIT GUM-CHITOSAN IMPREGNATED POLYMER NETWORK FILMS: FORMULATION AND SUBSTANTIAL DEPICTION

  • Meenu Nagpal Department of Pharmaceutics, Chandigarh College of Pharmacy, Mohali - 140 307, Punjab, India
  • Geeta Aggarwal Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi - 110 017, India.
  • Upendra Kumar Jain Department of Pharmaceutics, Chandigarh College of Pharmacy, Mohali - 140 307, Punjab, India
  • Jitender Madan Department of Pharmaceutics, Chandigarh College of Pharmacy, Mohali - 140 307, Punjab, India

Abstract

 

 Objective: The present research is aimed at formulation and evaluation of okra fruit gum (OFG)-chitosan (CH) impregnated polymer network films.

Methods: The film forming property of the gum attained from fruits of Abelmoschus esculentus was enhanced by co-processing it with CH. Estimation of properties including swelling index (SI), film volume, volume index, film surface contact angle with buffer solutions (pH 1.2, 7.4 or 6.8), work of adhesion (Wa), and spreading coefficient was done.

Results: The contact angle and SI of OFG-CH film in both acidic and alkaline buffers were witnessed to be lowest when equated with the films prepared with difference in ratios of both gum and CH. Moreover, the Wa and spreading coefficient were less for this film. These results could be attributed to the optimum interaction between –COO− groups of gum and -NH3+ groups of CH.

Conclusion: The actual nature of the film found to be tough, flexible, and water resistant. Hence, the results have shown that the films produced have a high potential for use in modified drug release and in food and pharmaceuticals.

Keywords: Chitosan, Contact angle, Okra, Film, Spreading coefficient, Work of adhesion.

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Nagpal, M., G. Aggarwal, U. K. Jain, and J. Madan. “OKRA FRUIT GUM-CHITOSAN IMPREGNATED POLYMER NETWORK FILMS: FORMULATION AND SUBSTANTIAL DEPICTION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 10, Sept. 2017, pp. 219-22, doi:10.22159/ajpcr.2017.v10i10.20362.
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