THE IMPACT OF ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY TO SUCCESFUL TUBERCULOSIS TREATMENT IN INDONESIA


Nisa Maria, Maksum Radji, Erlina Burhan

Abstract


 

 Objective: This study aimed to evaluate the impact of antituberculosis (anti-TB) drug-induced hepatotoxicity (DIH) to outcome TB treatment.

Methods: A cohort retrospective study conducted at a tertiary hospital in Jakarta - Indonesia, from the period of 2013-2016. A total of 76 samples of TB patient with and without anti-TB DIH were analyzed.

Results: Successful outcome TB treatment for TB patient with anti-TB DIH is 47.4% compared to TB patient without anti-TB DIH is 78.9%. Relative risk (RR) analysis showed that risk of unsuccessful TB treatment for TB patient with anti-TB DIH is 2.50 fold higher (95% confidence interval: 1.259- 4.960) than TB patient without anti-TB DIH. Age, sex, and comorbidities are not statistically significant to outcome TB treatment. For TB patient with anti-TB DIH, onset anti-TB DIH and recurrence anti-TB DIH also not statistically significantly influence outcome TB. The mean duration of treatment for a successful outcome for TB patient with and without anti-TB DIH was statistically significant (p<0.05), respectively, 8.44±1.85 and 6.52±0.93 months.

Conclusion: Anti-TB DIH increases the risk of unsuccessful and prolonged duration TB treatment.


Keywords


Antituberculosis, Drug-induced hepatotoxicity, Outcome.

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About this article

Title

THE IMPACT OF ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY TO SUCCESFUL TUBERCULOSIS TREATMENT IN INDONESIA

Topics

Pharmacy (Clinical Pharmacy)

Keywords

Antituberculosis, Drug-induced hepatotoxicity, Outcome.

DOI

10.22159/ajpcr.2017.v10i11.20386

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 11 November 2017 Page: 194-198

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

24 Views | 57 Downloads

Authors & Affiliations

Nisa Maria
Department of Pharmacy, Faculty of Pharmacy, University of Indonesia, Depok, Indonesia.
Indonesia

Maksum Radji
Department of Pharmacy, Faculty of Pharmacy, University of Indonesia, Depok, Indonesia.
Indonesia

Erlina Burhan
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia. Department of Pulmonology and Respiratory, Persahabatan Hospital, Jakarta, Indonesia.
Indonesia


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