ASSOCIATION OF LIPID PROFILES WITH 10-YEAR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK: STUDY AMONG SUBJECTS IN SLEMAN DISTRICT OF YOGYAKARTA INDONESIA


Rita Suhadi, Dita Maria Virginia, Christianus Heru Setiawan

Abstract


 

 Objectives: The subjects in the Sleman District of Yogyakarta had medium Framingham risk score (FRS) in the preceding year study. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk was a newer risk estimator than FRS. This study aimed to associate the lipid profiles with the ASCVD risk.

Methods: The study was conducted with a cross-sectional design and the subjects were selected with cluster random sampling. The association of lipid profiles and ASCVD risk was analyzed with Mann–Whitney/Kruskal–Wallis tests and Spearman’s rho correlation, whereas the categorical scores within sub-groups were analyzed Chi-square statistics, respectively.

Results: The eligible subjects (n=221) had the age at 51.7±8.1 years, systolic/diastolic blood pressure 136.8±22.4/85.0±12.4 mmHg, total-cholesterol (total-C), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride at 202.0±34.9 mg/dl, 52.6±12.5 mg/dl, 126.3±30.0 mg/dl, and 135.9±95.4 mg/dl, respectively; with hypertension treatment 16.7%, smoking 52.9%, diabetes 10.4%, and the median ASCVD risk at 4.4 (0.2-41.4). The ASCVD risk has significant association with non-lipid profiles, total-C, lipid ratio of triglyceride/HDL-C, total-C/HDL-C, and LDL-C/HDL-C, to a lesser extent, HDL-C, LDL-C, and triglyceride.

Conclusion: The 10-year ASCVD risk of the subjects was categorized as low and had a significant association with total-C and lipid ratio of triglyceride/ HDL-C, total-C/HDL-C, and LDL-C/HDL-C.


Keywords


Atherosclerotic cardiovascular disease, 10-year atherosclerotic cardiovascular disease risk, lipid profiles, cholesterol, ratio totalcholesterol/ high-density lipoprotein-cholesterol-C, ratio low-density lipoprotein-cholesterol/high-density lipoprotein-ch

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About this article

Title

ASSOCIATION OF LIPID PROFILES WITH 10-YEAR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK: STUDY AMONG SUBJECTS IN SLEMAN DISTRICT OF YOGYAKARTA INDONESIA

Topics

Clinical Pharmacy; Pharmacotherapy in Cardiovascular Disease

Keywords

Atherosclerotic cardiovascular disease, 10-year atherosclerotic cardiovascular disease risk, lipid profiles, cholesterol, ratio totalcholesterol/ high-density lipoprotein-cholesterol-C, ratio low-density lipoprotein-cholesterol/high-density lipoprotein-ch

DOI

10.22159/ajpcr.2017.v10i12.20675

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 166-170

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

10 Views | 33 Downloads

Authors & Affiliations

Rita Suhadi
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Sanata Dharma University, Jl. Affandi Yogyakarta 55002,Indonesia.
Indonesia

Dita Maria Virginia
Sanata Dharma University
Indonesia

Christianus Heru Setiawan
Sanata Dharma University
Indonesia


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