SUPPLEMENTATION WITH 2:1 RATIO OF N-6:N-3 POLYUNSATURATED FATTY ACID IMPROVES LIVER STEATOSIS AND SERUM CYTOKINE LEVELS IN YOUNG OBESE BALINESE WOMEN: A RANDOMIZED CLINICAL TRIAL


I Wayan Weta, Mahadewa Tjokorda Gb, Wayan P Sutirtayasa, Anak Agung Ngurah Subawa, Safarina G Malik, I Putu Eka Widyadharma

Abstract


 

 Objectives: In addition to the rise in obesity prevalence globally, morbidity due to nonalcoholic fatty liver disease is increasing. Primary modalities for preventing and managing this problem include dietary modification and improved physical activities. A daily diet with a low n-6:n-3 polyunsaturated fatty acid (PUFA) ratio is suspected to contribute to ameliorating liver steatosis (LS). The present study was conducted to elucidate the effects of an n-6:n-3 PUFA ratio of 2:1 in alleviating LS.

Methods: Twenty-four young obese women with LS were recruited from Denpasar, Bali, Indonesia. They were randomly allocated to an intervention or control group. Both groups were given linoleic acid:α-linolenic acid at ratios of 2035:970 and 240:100 g, respectively, for 12 weeks. Baseline and end-line data were obtained. All patients were advised to maintain their daily energy intake no more than 1500 kcal and to perform structured physical exercises once a week.

Results: The intervention significantly decreased the body fat (body mass index, p=0.040; triglyceride, p=0.008) and serum tumor necrosis factor-α (TNF-α) levels (p=0.002) and increased serum interleukin-10 (IL-10) levels (p=0.004). The severity of LS was reduced through the intervention (odds ratio=0.064; 95% confidence interval=0.013-0.310; p=0.001).

Conclusion: An increased intake of 2:1 n-6:n-3 PUFA ratio alleviated LS, decreased body fat composition and serum TNF-α levels, and increased serum IL-10 levels.


Keywords


young obese women, 2:1 n-6:n-3 PUFA ratio, cytokines, liver steatosis

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About this article

Title

SUPPLEMENTATION WITH 2:1 RATIO OF N-6:N-3 POLYUNSATURATED FATTY ACID IMPROVES LIVER STEATOSIS AND SERUM CYTOKINE LEVELS IN YOUNG OBESE BALINESE WOMEN: A RANDOMIZED CLINICAL TRIAL

Topics

Biomedical science; Nurition

Keywords

young obese women, 2:1 n-6:n-3 PUFA ratio, cytokines, liver steatosis

DOI

10.22159/ajpcr.2017.v10i12.20851

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 74-79

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

42 Views | 37 Downloads

Authors & Affiliations

I Wayan Weta
Department of Community and Preventive Medicine, Clinical Nutrition, Faculty of Medicine, Udayana University, Sanglah Hospital, Denpasar, Bali, Indonesia.
Indonesia

Mahadewa Tjokorda Gb
Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
Indonesia

Wayan P Sutirtayasa
Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
Indonesia

Anak Agung Ngurah Subawa
Department of Clinical Pathology, Faculty of Medicine, Sanglah Hospital, Denpasar, Bali, Indonesia.
Indonesia

Safarina G Malik
Eijkman Institute for Molecular Biology, Ministry of Research Technology and Higher Education, Republic of Indonesia, Jakarta, Indonesia.
Indonesia

I Putu Eka Widyadharma
Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
Indonesia


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