DETERMINATION OF BIOLOGICAL ACTIVITIES OF THREE MARINE ALGAE COLLECTED FROM VISAKHAPATNAM COAST


Satya Lakshmi S

Abstract


 

 Objective: Determination of biological activities of marine algae collected from the Visakhapatnam coastal region.

Methods: Antibacterial activity of algal extracts determined by the well diffusion method, antioxidant activity was determined by reducing power (RP) method and 1, 1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging method finally anti-inflammatory activity was determined by human red blood cell stabilization method and egg albumin method.

Results: Methanolic extracts of three algae have potential inhibition activity against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus. Green alga Enteromorpha compressa has better antioxidant activity compared to the Gracilaria arcuata and Ulva fasciata when tested in RP and DPPH method. U. fasciata found good anti-inflammatory activity among the selected three algae.

Conclusion: The three tested algae exhibited significant antibacterial and antioxidant activity compared to anti-inflammatory activity. These bioactive compounds containing macroalgae may find their commercial potential in medicine, food, and cosmetic industry


Keywords


Visakhapatnam coast, Anti-inflammatory, Antioxidant, Antibacterial, 1, 1-diphenyl-2-picryl-hydrazil, Egg albumin.

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References


Lee J, Ko N, Min DB. Reactive oxygen species, aging, and antioxidative nutraceuticals. Compr Rev Food Sci Food Saf 2004;3:21-33.

Zbakh H, Chiheb H, Bouziane H, Sanchez VM, Riadi H. Antibacterial activity of benthic marine algae extracts from the Mediterranean coast of Morocco. J Microbiol Biol Food Sci 2012;2(1):219-28.

Bouhlal R, Haslin C, Chermann JC, Colliec-Jouault S, Sinquin C, Simon G, et al. Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales). Mar Drugs 2011;9(7):1187-209.

Na HJ, Moon PD, Lee HJ, Kim HR, Chae HJ, Shin T, et al. Regulatory effect of atopic allergic reaction by Carpopeltis affinis. J Ethn 2005;1(101):43-8.

Dayong S, Jing L, Shuju G, Lijun H. Antithrombotic effect of bromophenol, the alga-derived thrombin inhibitor. J Biotechnol 2008;136:577-88.

Kim SK, Thomas NV, Li X. Anticancer compounds from marine macroalgae and their application as medicinal foods. Adv Food Nutr Res 2011;64(64):213-24.

Bhadury P, Wright PC. Exploitation of marine algae: Biogenic compounds for potential antifouling applications. Planta 2004;219(4):561-78.

Devi GK, Manivannan K, Thirumaran G, Rajathi FA, Anantharaman P. In vitro antioxidant activities of selected seaweeds from Southeast coast of India. Asian Pac J Trop Med 2011;4(3):205-11.

Kharkwal H, Joshi DD, Panthari P, Pant MK, Kharkwal AC. Algae as future drugs. Asian J Pharm Clin Res 2012;3(5):1-4.

Kolanjinathan K, Ganesh P, Saranraj P. Pharmacological importance of seaweeds. World J Fish Mar Sci 2014;6(1):10-5.

Rani DS, Rao PY, Sirisha IR. Distribution of seaweeds along the coastal waters of Visakhapatnam, east coast of India. J Int Acad Res Multidiscip 2015;3(1):154-62.

Jayaprakash GK, Singh RP, Sakariah KK. Antioxidant activity of grape seed extracts on peroxidation models in vitro. Food Chem 2001;3(73):285-90.

Oyaizu M. Studies on products of browning reaction prepared from glucosamine. Jpn J Nutr 1986;44:307-14.

Zhang WW, Duan XJ, Huang HL, Zhang Y, Wang BG. Evaluation of 28 marine algae from the Quingdao coast for anti-oxidative capacity and determination of antioxidant efficiency and total phenolic content of fractions and sub fractions derived from Symphyocladia latiuscula (Rhodomelaceae). J Appl Phycol 2007;19(2):97-108.

Vana JR, Botting RM. New insight into the mode of action of anti-inflammatory drugs. Inflamm Res 1995;1(44):1-10.

Bhattacharya S, Chandra S, Dey P, Chatterjee P. Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein. Asian Pac J Trop Biomed 2012;1(2):178-80.

Meenakshi S, Gnanambigai DM, Mozhi ST, Arumugam M, Balasubramanian T. Total flavanoid and in vitro antioxidant, antibacteria from seaweeds of Rameshwaram coast. Glob J Pharm 2009;3(2):59-62.

Cox S, Abu-Ghannam N, Gupta S. An assessment of the antioxidant and antimicrobial activity of six species of edible Irish seaweeds. Int Food Res J 2010;17:205-20.

Srivastava N, Saurav K, Mohanasrinivasan V, Kannabiran K, Singh M. Antibacterial potential of macroalgae collected from the Madappam coast, India. Br J Pharm Toxicol 2010;1(2):72-6.

Sujatha L, Govardhan TL, Rangaiah GS. Antibacterial activity of green sea weeds on oral bacteria. Indian J Nat Prod Res 2012;3(3):328-33.

Repetto MG, Liesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res 2002;35(5):523-34.

Pandian A, Baskaran K, Subashini R. Free radical scavenging and antioxidant properties of marine red algae hypnea musciformis. Int J Pharm Pharm Sci 2015;7(8):227-31.

Satoskar RS, Bhandarkar SD, Ainapure SS. Pharmacology and pharmacotherapeutics. In: Pharmacotherapy of Gout, Rheumatoid Arthritis and Osteoarthritis. 18th ed. Mumbai: Popular Prakasham Publication; 2003.

Marijana K, Branislav R, Tatjana S. Biological activities of two macroalgae from Adriatic coast of Montenegro. Saudi J Biol Sci 2015;22(4):390-7.

Shalaby EA, Shanab AM, El-Fayoumy EA. Enteromorpha compressa exhibits potent antioxidant activity. J Biomed Biotechnol 2011;726405:1-11.

Umapathy E, Ndebia EJ, Meeme A, Adam B, Menziura P, Nkeh-Chungag BN, et al. An experimental evaluation of Albuca setosa aqueous extract on membrane stabilization, protein denaturation and white blood cell migration during acute inflammation. J Med Plant Res 2010;4(9):789-95.

Jatap VA, Agasimundim YS, Jayachandran E, Sathe BS. In vitro anti-inflammatory activity of 2-amino-3-(substituted benzylidinecarbohydrazide)-4,5,6,7-tetrahydrobenzothiophene. J Pharm Res 2011;4(2):378-9.

Priyadarsini PM, Satyabrata DS, Lakshman N, Ranjan PC. Uses of seaweed and its application to human welfare: A review. Int J Pharm Pharm Sci 2016;8(10):12-20.




About this article

Title

DETERMINATION OF BIOLOGICAL ACTIVITIES OF THREE MARINE ALGAE COLLECTED FROM VISAKHAPATNAM COAST

Topics

original research in biotechnology

Keywords

Visakhapatnam coast, Anti-inflammatory, Antioxidant, Antibacterial, 1, 1-diphenyl-2-picryl-hydrazil, Egg albumin.

DOI

10.22159/ajpcr.2017.v10i12.20857

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 274-279

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

12 Views | 34 Downloads

Authors & Affiliations

Satya Lakshmi S
Department of Pharmacy, Pharmaceutical Biotechnology Division, Vignan Institute of Pharmaceutical Technology, Visakhapatnam, Andhra Pradesh, India.
India


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