EVALUATION OF RESPONSE TO ANTIHYPERTENSIVE’S IN PREECLAMPSIA AND GESTATIONAL HYPERTENSION CASES WITH DIFFERENT ACE GENE INSERTION/DELETION GENOTYPES


Mohd Ishaq, Arshiya Afreen, Fatma Ali, Juhi Aziz, Nida Makeen, Nusrath Fathima, P Padmaja, Mohd Mohiuddin

Abstract


 

 Objective: The objective of this research study was to investigate if there exists a relationship between angiotensin converting enzyme (ACE) genes insertion/deletion (I/D) genotypes and the antihypertensive treatment being received by preeclampsia (PE) and gestational hypertension (GH) patients.

Methods: A total of 50 PE and 35 GH cases were included. ACE gene I/D genotyping was carried out on the blood samples of cases and correlated with the antihypertensive treatment being received by these patients. Details of antihypertensives being received by them were nifedipine (a calcium channel blocker 10 mg) and methyldopa (an alpha 2 receptor agonist 250 mg) which is considered as the first-line of treatment. 30 normotensive pregnant women of comparable gestational period served as controls.

Results: It was observed that a combination of calcium channel blocker (nifedipine 10 mg), as well as alpha 2 agonist (methyldopa 250 mg), was required in patients with D’ allele containing genotypes. However, PE and GH patients with II genotype as well as those of GH patients responded well to either nifedipine or methyldopa. If confirmed these results appear to be of clinical significance as prior knowledge of ACE I/D genotypes will be useful in the management of PE cases in general and severe PE cases in particular.

Conclusion: Prior knowledge of ACE I/D genotypes appears to be helpful in the management of PE and GH cases.


Keywords


Preeclampsia, Gestational hypertension, Response to antihypertensive’s, Angiotensin converting enzyme insertion/deletion genotypes.

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About this article

Title

EVALUATION OF RESPONSE TO ANTIHYPERTENSIVE’S IN PREECLAMPSIA AND GESTATIONAL HYPERTENSION CASES WITH DIFFERENT ACE GENE INSERTION/DELETION GENOTYPES

Topics

Lifescience; Genetics

Keywords

Preeclampsia, Gestational hypertension, Response to antihypertensive’s, Angiotensin converting enzyme insertion/deletion genotypes.

DOI

10.22159/ajpcr.2017.v10i12.20868

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 216-219

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

40 Views | 37 Downloads

Authors & Affiliations

Mohd Ishaq
Salar E Millat Research Centre For Cellular and Molecular Medicine, Princess Esra Hospital, Deccan College of Medical Science. Shahlibanda-500065
India

Arshiya Afreen
Deccan School of Pharmacy,PHARM-D (Doctor of PHARMACY),Deccan College of MedicalSciences (DCMS), Hyderabad.
India

Fatma Ali
Deccan School of Pharmacy,PHARM-D (Doctor of PHARMACY),Deccan College of MedicalSciences (DCMS), Hyderabad.

Juhi Aziz
Deccan School of Pharmacy,PHARM-D (Doctor of PHARMACY),Deccan College of MedicalSciences (DCMS), Hyderabad.

Nida Makeen
Deccan School of Pharmacy,PHARM-D (Doctor of PHARMACY),Deccan College of MedicalSciences (DCMS), Hyderabad.
India

Nusrath Fathima
Department of Genetics , Osmania University,-500007
India

P Padmaja
Department of Obstetrics & Gynaecology, Princess Esra Hospital, Hyderabad-500065.
India

Mohd Mohiuddin
Deccan School of Pharmacy,PHARM-D (Doctor of PHARMACY),Deccan College of MedicalSciences (DCMS), Hyderabad.
India


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