HEPATOPROTECTIVE EFFECT OF CHENOPODIUM QUINOA SEED AGAINST CCL4-INDUCED LIVER TOXICITY IN SWISS ALBINO MALE MICE


Sneha Saxena, Lata Shahani, Pradeep Bhatnagar

Abstract


 

 Objective: To study the effect of Quinoa seed on carbon tetrachloride (CCL4)-induced liver toxicity in Swiss albino male mice.

Methods: Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl4-treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosphatase and liver antioxidant enzyme level of lipid peroxidation, superoxide dismutase, and reduced glutathione were measured. Further, histopathological analysis of liver was also conducted.

Results: The results showed that the treatment with Quinoa seed powder significantly reduced CCl4-induced elevated serum level of hepatic enzymes and restored the level of liver antioxidant enzymes toward the normal levels, which was also confirmed by histopathological studies.

Conclusion: Results of the present study concluded that the Quinoa seed (Chenopodium quinoa) showed hepatoprotective effect against CCl4-induced liver damage in Swiss albino male mice.


Keywords


Quinoa seed, Carbon tetrachloride, Liver marker enzymes, Histopathological studies.

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About this article

Title

HEPATOPROTECTIVE EFFECT OF CHENOPODIUM QUINOA SEED AGAINST CCL4-INDUCED LIVER TOXICITY IN SWISS ALBINO MALE MICE

Topics

Department of Zoology

Keywords

Quinoa seed, Carbon tetrachloride, Liver marker enzymes, Histopathological studies.

DOI

10.22159/ajpcr.2017.v10i11.20918

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 11 November 2017 Page: 273-276

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

40 Views | 47 Downloads

Authors & Affiliations

Sneha Saxena
Department of Zoology, The IIS University, ICG Campus, Gurukul Marg, SFS, Mansarovar, Jaipur - 302 020, Rajasthan, India.
India

Lata Shahani
Department of Zoology, The IIS University, ICG Campus, Gurukul Marg, SFS, Mansarovar, Jaipur - 302 020, Rajasthan, India.
India

Pradeep Bhatnagar
Department of Zoology, The IIS University, ICG Campus, Gurukul Marg, SFS, Mansarovar, Jaipur - 302 020, Rajasthan, India.
India


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