CARDIOPROTECTIVE EFFECT OF PHYLLANTHUS FRATERNUS LEAVES EXTRACT AGAINST CYCLOPHOSPHAMIDE - INDUCED MYOCARDIAL INJURY IN RATS


Rakesh Singh Moirangthem, Ngangom Gunindro, Dipdeba Singh Takhellambam, Sucheta Devi Khuraijam, Meena N, Rita S

Abstract


Objectives: This study was undertaken to investigate the possible protective effect of aqueous extract of Phyllanthus fraternus (AEPF) leaves against cyclophosphamide (CP) induced myocardial toxicity in rats.

Methods: Wistar rats were given CP single intraperitoneally injection (200 mg/kg) on day 1 of the experiment and two doses of AEPF (200 mg/kg and 400 mg/kg) p.o. daily for 10 days. Cardiac biomarker enzymes such as creatinine kinase (CK), CK isoenzyme MB, lactate dehydrogenase, alkaline phosphatase, alanine transaminase, and aspartate transaminase were determined. Histopathological examinations of the hearts were done.

Results: CP treated groups exhibited significantly increased in cardiac biomarker enzymes. Treatment with AEPF prevented the elevation of these enzymes. Potential protective effect was also seen in histopathological examination of the heart characterized by decreased myocardium cell damages in AEPF treatment group.

Conclusion: The study showed the protective role of AEPF against CP-induced myocardial injury. The possible role of antioxidant activity is anticipated.


Keywords


Phyllanthus fraternus, Cyclophosphamide, Cardiotoxicity, Cardiac biomarkers, Histopathological.

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About this article

Title

CARDIOPROTECTIVE EFFECT OF PHYLLANTHUS FRATERNUS LEAVES EXTRACT AGAINST CYCLOPHOSPHAMIDE - INDUCED MYOCARDIAL INJURY IN RATS

Topics

PHARMACOLOGY

Keywords

Phyllanthus fraternus, Cyclophosphamide, Cardiotoxicity, Cardiac biomarkers, Histopathological.

DOI

10.22159/ajpcr.2017.v10i12.21003

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 280-285

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

14 Views | 30 Downloads

Authors & Affiliations

Rakesh Singh Moirangthem
Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
India

Ngangom Gunindro
Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
India

Dipdeba Singh Takhellambam
Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
India

Sucheta Devi Khuraijam
Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
India

Meena N
Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
India

Rita S
Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
India


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