ANTICANCER ACTIVITY OF GARCINIA MORELLA CHLOROFORM FRACTION AND ITS ACTIVE COMPOUND GARCINOL ON NEUROBLASTOMA


Bhaswati Choudhury, Raghuram Kandimalla, Rupjyoti Bharali, Jibon Kotoky

Abstract


Objective: The aim of the present study is to evaluate the anticancer activity of G. morella fruit chloroform fraction and its isolated bioactive molecule garcinol on neuroblastoma cell line (SH-SY5Y).

Method: Methanol extraction was performed for the G. morella fruits through cold maceration and further fractionated with chloroform. The presence of Garcinol was confirmed by measuring the melting point. Further, the bioactive chloroform fraction and pure Garcinol was tested for anticancer activity against SH-SY5Y cells through MTT assay.

Result: The present study reveals the anticancer ability of bioactive chloroform fraction of G. morella fruit and its active molecule garcinol.

Conclusion: G. morella fruit and its bioactive compound Garcinol have significant activity against neuroblastoma. This study opens an avenue to further elucidate the mechanism of action and development of alternative treatment of this dreaded disease.

 


Keywords


Garcinia morella, Neuroblastoma, Garcinol, Anticancer activity.

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About this article

Title

ANTICANCER ACTIVITY OF GARCINIA MORELLA CHLOROFORM FRACTION AND ITS ACTIVE COMPOUND GARCINOL ON NEUROBLASTOMA

Topics

Biological Sciences

Keywords

Garcinia morella, Neuroblastoma, Garcinol, Anticancer activity.

DOI

10.22159/ajpcr.2017.v10i12.21066

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 182-185

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

11 Views | 31 Downloads

Authors & Affiliations

Bhaswati Choudhury
Drug Discovery Laboratory, Life sciences division, Institute of Advanced studies in Science and technology, Drug Discovery Lab., Paschim Boragaon, Guwahati, Assam, India.
India

Raghuram Kandimalla
Drug Discovery Laboratory, Life sciences division, Institute of Advanced studies in Science and technology, Drug Discovery Lab., Paschim Boragaon, Guwahati, Assam, India.
India

Rupjyoti Bharali
Department of Biotechnology, Gauhati University, Guwahati, Assam, India.
India

Jibon Kotoky
Drug Discovery Laboratory, Life sciences division, Institute of Advanced studies in Science and technology, Drug Discovery Lab., Paschim Boragaon, Guwahati, Assam, India.
India


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