PHARMACOLOGICAL EVALUATION OF ANTINEOPLASTIC ACTIVITY OF HYDROETHANOLIC EXTRACT OF UNRIPE FRUIT OF CARICA PAPAYA LINN USING ANIMAL MODEL


Padmam Praveena, Jayapalan Prasannakumari Jethinlalkhosh, Victor Arokia Doss

Abstract


Objective: This study was undertaken to screen the effect of administration of various doses of hydroethanolic extract of unripe fruit of Carica papaya L. (HEECP) against Dalton’s ascitic lymphoma (DAL) in Swiss albino mice.

Methods: DAL cells were injected intraperitoneally (1×106 cells) to each mouse and divided into various groups. The animals were treated with various doses (200 mg/kg and 400 mg/kg) of HEECP. A standard drug (5-fluorouracil, 20 mg/kg/day) was also used. The animals were evaluated for hematological and biochemical parameters and were compared with the same parameters in the standard by collecting blood from a retro-orbital blood vessel of mice.

Results: The life spans of the animals were increased. In the DAL tumor control group, the average life span of animals was found to be 45% whereas, 200 and 400 mg/kg of test drug showed increase in life span to 67% and 75%, respectively. Platelets count was significantly (p<0.001) decreased in cancer control group and was brought back to normal after treatment.

Conclusion: These observations suggest that the extract possesses antineoplastic effect against DAL.


Keywords


Antineoplastic,Carica papaya

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About this article

Title

PHARMACOLOGICAL EVALUATION OF ANTINEOPLASTIC ACTIVITY OF HYDROETHANOLIC EXTRACT OF UNRIPE FRUIT OF CARICA PAPAYA LINN USING ANIMAL MODEL

Topics

BIOCHEMISTRY;CLINICAL BIOCHEMISTRY

Keywords

Antineoplastic,Carica papaya

DOI

10.22159/ajpcr.2017.v10i12.21165

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 179-181

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

12 Views | 37 Downloads

Authors & Affiliations

Padmam Praveena
Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India.
India

Jayapalan Prasannakumari Jethinlalkhosh
Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India.
India

Victor Arokia Doss
Department of Biochemistry, P S G College of Arts and Science, Coimbatore, Tamil Nadu, In
India


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