MUPIROCIN RESISTANCE IN STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE HOSPITAL OF SOUTH INDIA – A PROSPECTIVE STUDY

  • Malavalli Venkatesh Bhavana Department of Laboratory Medicine – Microbiology, Manipal Hospital, HAL Airport Road, Kodihalli, Bengaluru, Karnataka, India.
  • Sangeeta Joshi Department of Microbiology, NH SRCC Children’s Hospital, Mumbai, Maharashtra, India.
  • Ranjeeta Adhikary Department of Laboratory Medicine – Microbiology, Manipal Hospital, HAL Airport Road, Kodihalli, Bengaluru, Karnataka, India.
  • Hosdurg Bhaskar Beena Department of Laboratory Medicine – Microbiology, Manipal Hospital, HAL Airport Road, Kodihalli, Bengaluru, Karnataka, India.

Abstract

Objective: Mupirocin is a topical antibiotic used for the treatment of skin and soft tissue infections caused by Staphylococcus aureus and for the nasal decolonization of methicillin-resistant S. aureus (MRSA). The increasing reports of resistance to mupirocin are a matter of concern. We undertook this study to detect and differentiate the mupirocin resistance pattern and to analyze the susceptibility pattern among S. aureus isolates of our hospital.

Methods: This is a prospective laboratory-based study conducted during the period May–September 2014. Clinical samples that grew S. aureus during the study period were tested for mupirocin resistance using the 5 μg and 200 μg discs. Minimum inhibitory concentration (MIC) detection of resistant strains was performed using the E-test.

Results: Mupirocin resistance was seen in 4.81% of our S. aureus isolates; all of which exhibited high-level resistance with MIC ≥1024 μg/ml.

Conclusions: The resistance is bound to rise with the increased usage of mupirocin; regular testing will help in tackling this upcoming problem and in preserving this important antibiotic against MRSA.

Keywords: Staphylococcus aureus, Mupirocin, High- and low-level resistance.

Author Biography

Malavalli Venkatesh Bhavana, Department of Laboratory Medicine – Microbiology, Manipal Hospital, HAL Airport Road, Kodihalli, Bengaluru, Karnataka, India.

Specialist

Dept of Lab Medicine - Microbiology

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How to Cite
Venkatesh Bhavana, M., S. Joshi, R. Adhikary, and H. B. Beena. “MUPIROCIN RESISTANCE IN STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE HOSPITAL OF SOUTH INDIA – A PROSPECTIVE STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 1, Jan. 2019, pp. 98-100, doi:10.22159/ajpcr.2019.v12i1.21183.
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