ANTIMICROBIAL AND TOXICOLOGICAL STUDIES OF RICINODENDRON HEUDELOTII (BAILL.)


Omolara Faith Yakubu, Abiodun Humphrey Adebayo, Tolulope Oluwasomo Famakinwa, Oluwatobi Samuel Adegbite, Temitope Arike Ishola, Loretta Onoshownen Imonikhe, Oladipupo Alaba Adeyemi, Olufisayo Adebola Awotoye, Emeka Joshua Iweala

Abstract


 Objective: This work assessed the antimicrobial activity and toxicological consequence of the ethanolic extract of Ricinodendron heudelotii (Baill).

Methods: The antimicrobial potential of the leaf extract was investigated against 9 different microorganisms using the agar well diffusion method while the minimum inhibitory concentration (MIC) was ascertained. Toxicity evaluations were carried out on five groups of seven albino rats each for 28 days. Rats in Group A received normal saline, while those in Groups B, C, D, and E received 250, 500, 1000, and 2000 mg/kg body weight (b.w.) of the extract. After treatment, they were anesthetized, blood samples collected for biochemical assays; organs isolated, weighed, and processed for histopathological studies.

Results: The phytochemical screening showed the presence of glycosides, tannins, polyphenols, terpenoids, and alkaloids while saponin was absent. Antimicrobial effect was observed against 7 of the 9 microorganisms tested with inhibition zone and MIC ranging from 18 to 36 mm and 31.25 to 62.5 mg/mL, respectively. Liver function tests were significantly (p<0.05) increased, whereas no significant change in total protein and creatinine levels was observed. Histology showed a sinusoidal congestion and vacuolar degeneration of hepatocytes in groups administered higher doses, and a dose-dependent reduction was observed in some hematological parameters.

Conclusion: The results obtained suggest that the R. heudelotii may not induce significant toxic effect below 3600 mg/kg b.w. and could serve as an effective antibiotic.


Keywords


Ricinodendron heudelotii, Euphorbiaceae, Antimicrobial, Toxicology, Histology.

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About this article

Title

ANTIMICROBIAL AND TOXICOLOGICAL STUDIES OF RICINODENDRON HEUDELOTII (BAILL.)

Keywords

Ricinodendron heudelotii, Euphorbiaceae, Antimicrobial, Toxicology, Histology.

DOI

10.22159/ajpcr.2018.v11i1.21251

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 299-305

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Omolara Faith Yakubu
Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun, Nigeria.
Nigeria

Abiodun Humphrey Adebayo
Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun, Nigeria.
Nigeria

Tolulope Oluwasomo Famakinwa
Department of Biological Sciences, Baze University, Abuja, FCT, Nigeria.
Nigeria

Oluwatobi Samuel Adegbite
Department of Chemical Science, Osun State University, Osun State, Nigeria.
Nigeria

Temitope Arike Ishola
Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun, Nigeria.
Nigeria

Loretta Onoshownen Imonikhe
Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun, Nigeria.
Nigeria

Oladipupo Alaba Adeyemi
Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun, Nigeria.
Nigeria

Olufisayo Adebola Awotoye
Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun, Nigeria.
Nigeria

Emeka Joshua Iweala
Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun, Nigeria.
Nigeria


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