PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA, AN EMERGING POTENTIAL TARGET TO COMBAT METABOLIC DISORDER


Partha Sarathi Bairy

Abstract


 

 Day-by-day metabolic disorder/syndrome (MS) falling in love with current lifestyle status of everyone especially after study age group of people. If we look carefully around us, we will see evidence is growing up of diabetic, obese, and hypertensive population regularly. In urgencies of above view extensive literature survey has been done prioritizing prevalence of metabolic disorder and peroxisome proliferator-activated receptor-gamma (PPAR-γ) as potential target protein. This review covered current status of MS emphasizing diabetes along with its management criteria. Special importance is given to PPAR-γ exploring its metabolic regulation and structural orientation for understanding ligand-protein interaction. Development of PPAR-γ agonist thiazolidinediones (TZDs) and other pharmacodynamic importance of this nuclear receptor also discussed. Being as nuclear receptor more genomics exploitation needs to be done emphasizing minimization of cardiac adverse effect. Selective PPAR modulator (SPPRM), TZDs are the master regulator of adipogenesis and angiogenesis which makes TZD more interesting topic to explore. Developmental hierarchy suggests that in a few years from now PPAR-γ won’t be in the list of double edge sword.


Keywords


Metabolic disorder, Diabetes, Peroxisome proliferator-activated receptor-γ, Retinoid X receptor, Thiazolidinedione, Dyslipidemia.

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References


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About this article

Title

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA, AN EMERGING POTENTIAL TARGET TO COMBAT METABOLIC DISORDER

Keywords

Metabolic disorder, Diabetes, Peroxisome proliferator-activated receptor-γ, Retinoid X receptor, Thiazolidinedione, Dyslipidemia.

DOI

10.22159/ajpcr.2017.v10i12.21596

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 40-44

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

15 Views | 40 Downloads

Authors & Affiliations

Partha Sarathi Bairy
Department of Pharmaceutical Sciences, SBSPGI, Balawala, Dehradun, Uttarakhand-248161. India
India


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