AMELIORATION OF ALUMINUM- AND FLUORIDE-INDUCED BEHAVIORAL ALTERATIONS THROUGH RESVERATROL IN RATS.


Chandra Shakar Reddy Nallagouni, Nageshwar Mesram, Pratap Reddy Karnati

Abstract


 Objective: The objective of the study was to investigate the ameliorative effects of resveratrol against aluminum- and fluoride-altered neurobehavioral activities.

Methods: Aluminum chloride (100 mg/kg body weight [bw])+sodium fluoride (10 mg/kg bw), aluminum chloride (100 mg/kg bw) + sodium fluoride (10 mg/kg bw) + resveratrol (30 mg/kg bw), and resveratrol (30 mg/kg bw) alone were given orally to II, III, and IV groups, respectively, and Group-I was served as control for 8 weeks. The bw, brain weight, grip strength, learning ability, and behavioral activities were assayed.

Results: The results showed significantly (*p<0.05) altered body and brain weights, learning ability, grip strength, and behavioral activities in Group- II, whereas significant (*p<0.05) reversal was observed in Group-III.

Conclusion: Taken together, the above findings conclude that resveratrol ameliorated aluminum and fluoride-altered neurobehavioral activities.


Keywords


Aluminum, Fluoride, Resveratrol, Weight, Behavior.

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About this article

Title

AMELIORATION OF ALUMINUM- AND FLUORIDE-INDUCED BEHAVIORAL ALTERATIONS THROUGH RESVERATROL IN RATS.

Keywords

Aluminum, Fluoride, Resveratrol, Weight, Behavior.

DOI

10.22159/ajpcr.2018.v11i1.21620

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 289-293

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Chandra Shakar Reddy Nallagouni
Department of Zoology, Neurobiology Lab, University College of Science, Osmania University, Hyderabad, Telangana, India.
India

Nageshwar Mesram
Department of Zoology, Neurobiology Lab, University College of Science, Osmania University, Hyderabad, Telangana, India.
India

Pratap Reddy Karnati
Department of Zoology, Neurobiology Lab, University College of Science, Osmania University, Hyderabad, Telangana, India.
India


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