CARDIOPROTECTIVE EFFECT OF INDIGOFERA TINCTORIA LINN. AGAINST MYOCARDIAL INFARCTION-INDUCED RATS


Shankaraiah Puligilla, Priyanka K

Abstract


 

 Objective: The aim and objective of the present study are to study the protective effects of ethanolic extract of Indica tinctoria (EEIT) in isoproterenol-induced acute myocardial infarction (AMI) in rats.

Methods: The effect of two doses of isoproterenol (5 mg/kg and 8.5 mg/kg body weight) changes in aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and total protein (TP) and lipid hydroperoxides, superoxide dismutase (SOD), and glutathione (GSH) in blood serum and heart homogenate, for the two consecutive days (29 and 30), were administered subcutaneously in rats in pre-treatment with EEIT for the 28-day study.

Results: There was increased the AST, ALT, LDH, CPK, and lipid peroxides levels and decreased the TP, SOD, GSH with Isoproterenol-induced group. Pre-treatment for 28 days with Indigofera tinctoria significantly (p<0.05) increased antioxidants (SOD , GSH) , TP levels and decreased the cardiotoxic agents significantly (p<0.05) such as LPO, AST, ALT, LDH, and CPK levels in treatment groups.

Conclusion: I. tinctoria contains beneficial bioactive photochemicals that have been protective effective against isoproterenol-induced AMI in rats.


Keywords


Indigofera tinctoria, Cardiotoxic, Oxidative stress, Isoproterenol, Antioxidants.

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About this article

Title

CARDIOPROTECTIVE EFFECT OF INDIGOFERA TINCTORIA LINN. AGAINST MYOCARDIAL INFARCTION-INDUCED RATS

Topics

Pharmacy

Keywords

Indigofera tinctoria, Cardiotoxic, Oxidative stress, Isoproterenol, Antioxidants.

DOI

10.22159/ajpcr.2018.v11i1.21643

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 67-69

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

107 Views | 154 Downloads

Authors & Affiliations

Shankaraiah Puligilla
Department of Pharmacy, Chaitanya College of Pharmacy Education and Research, Hanamkonda, Warangal, Telangana, India.
India

Priyanka K
Department of Pharmacy, SRR College of Pharmaceutical Sciences, Volbhapur, Karimnagar, Telangana, India.
India


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