ASSOCIATION OF ANTI-DOUBLE STRANDED DNA ANTIBODIES, C-REACTIVE PROTEIN, AND ERYTHROCYTE SEDIMENTATION RATE FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN TAMIL NADU.


Natesan Manikandan, Marimuthu Ragavan Rameshkumar, Rajeshwari S, Narasingam Arunagirinathan

Abstract


 Objective: To determine the serum levels of anti-double stranded DNA (anti-dsDNA) antibodies, serum C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in patients with systemic lupus erythematosus (SLE) from Tamil Nadu, and elucidate their correlation level.

Methods: Blood samples were collected from 100 SLE patients (mean age 39 years) attended to the Rheumatology Care Centre, Rajiv Gandhi Government General Hospital, Chennai. Anti-dsDNA antibodies IgG in SLE patients were analyzed by Enzyme-linked Immunosorbent Assay, and CRP was measured by turbidimetry. ESR was measured by Westergren method.

Results: In a total of 100 SLE patients, 72 cases were positive for anti-dsDNA antibody. The mean level of anti-dsDNA antibodies in 72 SLE patients was 102 IU/ml. Among the 100 SLE cases, 92 cases (92%) had elevated levels of CRP and their mean level was 11 ± 4 mg/L. The mean ESR levels were high in SLE patients (56 ± 20 mm/hr). Significant association of anti-dsDNA antibodies with ESR (r = 0.357; p < 0.001) and CRP (r = 0.81; p = 0.023) was found.

Conclusion: Anti-dsDNA antibodies had a significant association with CRP and ESR. The result of our study suggests an association of anti-dsDNA antibodies with ESR and CRP and was linked with SLE disease progression.

 


Keywords


Anti-double stranded DNA antibody, C-reactive protein, Erythrocyte sedimentation rate, Systemic lupus erythematosus.

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About this article

Title

ASSOCIATION OF ANTI-DOUBLE STRANDED DNA ANTIBODIES, C-REACTIVE PROTEIN, AND ERYTHROCYTE SEDIMENTATION RATE FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN TAMIL NADU.

Keywords

Anti-double stranded DNA antibody, C-reactive protein, Erythrocyte sedimentation rate, Systemic lupus erythematosus.

DOI

10.22159/ajpcr.2018.v11i1.21670

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 214-216

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

102 Views | 146 Downloads

Authors & Affiliations

Natesan Manikandan
Department of Microbiology and Biotechnology, Presidency College, Chennai, Tamil Nadu, India.
India

Marimuthu Ragavan Rameshkumar
Department of Microbiology and Biotechnology, Presidency College, Chennai, Tamil Nadu, India.
India

Rajeshwari S
Department of Rheumatology,Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.
India

Narasingam Arunagirinathan
Department of Microbiology and Biotechnology, Presidency College, Chennai, Tamil Nadu, India.
India


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