FORMULATION OF POLYHERBOMINERAL MATRICES FOR TREATMENT OF OSTEOPOROSIS


Shende Mulchand, Mendhekar Seema

Abstract


 Objective: Herbal drugs are finding the new source of promising drugs for the treatment and cure of various ailments. The present research work deals with the formulation and evaluation of herbomineral formulation indicated for osteoporosis.

Materials and Methods: The aqueous extract of Terminalia arjuna (ARJ), Asthisamhara (ASTM), Gokhru (GKH), Ashwagandha (ASG) and dried powder of drugs Sunthi (ST), Padmakashta (PDMS), Laksha (PLSH) and Jestamadha were prepared and formulated into a herbomineral tablet with organic calcium viz.; Godanti Bhasma (Godan) and Kukkutandatvak Bhasma (Kukk) by wet granulation.

Results: The prepared tablets were evaluated for various parameters such as colour, average weight, hardness, friability and disintegration time, which were found acceptable as per pharmacopoeial specifications. The weight variation (450 mg±10%), pH (4.58), disintegration time (17 min) and hardness (1.25 kg/cm2) were found within acceptable range. The quantitative estimation of calcium by atomic absorbance spectrophotometry was carried out using ethanol-water solvent extraction method and found 76.27 ± 0.439 mg/tab of elemental calcium in optimized F4 formulation.

Conclusion: The developed herbomineral formulation is suitable for calcium deficiency by balancing hormonal imbalance and increases the rate of ossification of bone which helps to curing bone fracture, osteoporosis and calcium deficiency related problems.


Keywords


Polyherbomineral, In-vitro drug release, Principal component analysis.

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About this article

Title

FORMULATION OF POLYHERBOMINERAL MATRICES FOR TREATMENT OF OSTEOPOROSIS

Topics

Google Scholar, Scopus, Elsevier, EBSCO, SCI mago (SJR), CAS, CASSI (American Chemical Society), DOAJ (Directory of Open Acess Journal), Index Copernicus, ICAAP

Keywords

Polyherbomineral, In-vitro drug release, Principal component analysis.

DOI

10.22159/ajpcr.2018.v11i1.21777

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 217-223

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Shende Mulchand
Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati – 444 604, Maharashtra, India.
India

Mendhekar Seema
Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati – 444 604, Maharashtra, India.
India


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