DESIGN AND CHARACTERIZATION OF OROSLIPPERY BUOYANT TABLETS FOR RANITIDINE HYDROCHLORIDE


Nidhal K Maraie, Zeina D Salman, Nora Zawar Yousif

Abstract


 

 Objective: The goal behind of performing this study was to come out with an oroslippery buoyant ranitidine hydrochloride tablet to ease the swallowing process. Hence, the drug is released controllably in the stomach regardless of the effect on gastric emptying time.

Materials and Methods: The core of the buoyant containing 150 mg of the drug was compressed directly, and sodium bicarbonate was employed as an effervescent agent, besides, hydroxyl propyl methyl cellulose (HPMC) polymer was utilized in different grades in the formulation process. The prepared core was immersed in the coating dispersion, which was formulated using xanthan gum (slipping agent) and Kollicoat instant release (IR) (for film formation). According to the variables in the formulation process, floating properties varies along with the release profile of the drug; therefore, investigation of the effects of variables was conducted, including polymer type and concentration in the core part, and the effect of Kollicoat IR amount as well as the level of coating.

Results: According to this study, it was clearly obvious that T4 formulation, that consisted of HPMC K4M, after being dipped 2 times in dispersion of 0.3% xanthan gum and 14% Kollicoat IR, had provided an instant floating, moreover, the in vivo slipperiness was quite acceptable as well as the taste masking. Nevertheless, the percentage of drug release measured after 6 h was 90.15%.

Conclusion: The resultant formulas is quite promising to take the lead as new approach to easy swallowing tablets without need of water especially for patients with swallowing problems as well as it is floating tablet that can retain the drug in gastric cavity to be continuously released to ensure its maximum absorption and may improve its bioavailability.

 


Keywords


Ranitidine hydrochloride, Oroslippery tablet, Gastro retentive, Buoyant, Kollicoat infrared, Xanthan gum.

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About this article

Title

DESIGN AND CHARACTERIZATION OF OROSLIPPERY BUOYANT TABLETS FOR RANITIDINE HYDROCHLORIDE

Keywords

Ranitidine hydrochloride, Oroslippery tablet, Gastro retentive, Buoyant, Kollicoat infrared, Xanthan gum.

DOI

10.22159/ajpcr.2018.v11i1.21982

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 143-150

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

28 Views | 69 Downloads

Authors & Affiliations

Nidhal K Maraie
Department of Pharmaceutics, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.
Iraq

Zeina D Salman
Department of Pharmaceutics, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.
Iraq

Nora Zawar Yousif
Department of Pharmaceutics, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.
Iraq


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