STATUS OF PLASMA ELECTROLYTES, UREA, CREATININE, AND C-REACTIVE PROTEIN IN CANCER PATIENTS.


Olubunmi C Ojo, Modupe F Asaolu, Ajibade O Oyeyemi, Ibikunle Akinlua, Olorunfemi M Molehin, Olufisayo G Oyebanji

Abstract


 Objective: Cancer is a major health problem not only in developed countries but also in developing countries like Nigeria. This study was designed to study the status of plasma electrolytes, urea, creatinine, and C-reative proteins (CRPs) in freshly diagnosed cancer patients.

Methods: Plasma electrolytes (sodium [Na+], potassium [K+], chlorine [Cl-], and bicarbonate [HCO3-]), urea, creatinine, and CRP were estimated in four different types of cancer (liver, colon, cervical, and uterine) patients attending Ekiti State University Teaching Hospital Ado Ekiti Nigeria. A total of 250 patients (between age of 45 and 70 years) consisting of 50 patients in each cancer type and 50 normal subjects as control were considered in this study.

Results: The result obtained revealed a significant (p<0.05) increase in the plasma levels of Na+, Cl-, creatinine, and CRP in all the cancer types when compared with the control subjects. Plasma urea level decreased significantly in patients with colon (3.16±0.70 mmol/L) and liver (3.03±1.75 mmol/L) cancer when compared with the control subjects (4.80±1.12 mmol/L). K+ and HCO3_ level was not significantly (p>0.05) different in all cancer types when compared with the control subjects.

Conclusion: This study revealed a possible link between plasma electrolytes, creatinine, CRP, urea, and cancer which could be useful in the assessment and management of cancer.


Keywords


Electrolytes, Urea, Creatinine, C-reactive protein, Cancer.

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About this article

Title

STATUS OF PLASMA ELECTROLYTES, UREA, CREATININE, AND C-REACTIVE PROTEIN IN CANCER PATIENTS.

Topics

Biochemistry ; Clinical Biochemistry

Keywords

Electrolytes, Urea, Creatinine, C-reactive protein, Cancer.

DOI

10.22159/ajpcr.2018.v11i1.22033

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 268-270

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

21 Views | 31 Downloads

Authors & Affiliations

Olubunmi C Ojo
Department of Biochemistry, Faculty of Science, Ekiti State University Ado-Ekiti, P.M.B. 5363 Ado-Ekiti, Nigeria.
Nigeria

Modupe F Asaolu
Department of Biochemistry, Faculty of Science, Ekiti State University Ado-Ekiti, P.M.B. 5363 Ado-Ekiti, Nigeria.
Nigeria

Ajibade O Oyeyemi
Department of Biochemistry, Faculty of Science, Ekiti State University Ado-Ekiti, P.M.B. 5363 Ado-Ekiti, Nigeria.
Nigeria

Ibikunle Akinlua
Department of Biochemistry, Faculty of Science, Ekiti State University Ado-Ekiti, P.M.B. 5363 Ado-Ekiti, Nigeria.
Nigeria

Olorunfemi M Molehin
Department of Biochemistry, Faculty of Science, Ekiti State University Ado-Ekiti, P.M.B. 5363 Ado-Ekiti, Nigeria.
Nigeria

Olufisayo G Oyebanji
Department of Biochemistry, Faculty of Science, Ekiti State University Ado-Ekiti, P.M.B. 5363 Ado-Ekiti, Nigeria.
Nigeria


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