Sati Aarti, Bhatt Priyanka


 Alzheimer’s disease (AD) is a neurodegenerative disorder with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the Omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), and accordingly, administration of DHA has been proposed as a possible treatment for this pathology. DHA and its derivatives like 2-hydroxy DHA-(OHDHA) have a strong therapeutic potential to treat AD. Studies have demonstrated that DHA induced lipid modifications are paralleled with a reduction in amyloid-beta (Αβ) accumulation and full recovery of cognitive impairment. Omega-3 fatty acids also caused alterations in the subcellular distribution of secretases and reduced Αβ-induced tau protein phosphorylation as well. Furthermore, OHDHA enhanced the survival of neuron-like differentiated cells exposed to different insults such as oligomeric Αβ and N-methyl-D-aspartate-mediated neurotoxicity. In conclusion, this review focuses on the pleiotropic effects of Omega-3 fatty acids that might prove beneficial to treat AD.


Amyloid beta, Omega-3 fatty acids, Docosahexaenoic acid.

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Amyloid beta, Omega-3 fatty acids, Docosahexaenoic acid.





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Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 2 February 2018 Page: 54-58

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Authors & Affiliations

Sati Aarti
Department of Pharmacy, Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Science, Dehradun – 248 001, Uttarakhand, India

Bhatt Priyanka
Department of Pharmacy, Shri Ram Murti Smarak, College of Engineering and Technology (Pharmacy), Bareilly – 243 202, Uttar Pradesh, India

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