EXPLORING THE INTERRELATIONSHIP BETWEEN ELECTROLYTES, ANEMIA, AND GLYCOSYLATED HEMOGLOBIN (HBA1C) LEVELS IN TYPE 2 DIABETICS


Lavanya Rajagopal, Vinothkumar Ganesan, Saleh Mohammed Abdullah, Sundaram Arunachalam, Kumaresan Kathamuthu, Balaji Ramraj

Abstract


 

 Objective: The aim of this study is to analyze the interrelationship and pattern of electrolyte imbalance and compare the correlation between serum electrolytes, glycosylated hemoglobin (HbA1C), and hemoglobin (Hb) levels between Type 2 diabetic patients and non-diabetic subjects.

Methods: This study was conducted in 300 subjects (150 diabetics and 150 non-diabetics) and further categorized as anemic and non-anemic within each group. Blood samples were analyzed for HbA1C, hemoglobin, and serum electrolyte levels.

Results: Sodium (Na+) levels in diabetics were significantly lower and potassium (K+) as well as chloride (Cl−) levels were significantly higher, when compared with non-diabetics. A significant positive correlation between HbA1C and potassium as well as chloride levels in contrast to negative correlation with sodium levels was observed in both genders. Among diabetics with anemia, we found significantly lower sodium and higher potassium and chloride.

Conclusion: In diabetics, levels of sodium were significantly lower, and potassium as well as chloride was significantly higher when compared with non-diabetics. Our study clearly demonstrates an association between electrolytes, hemoglobin, and HbA1C levels in diabetes. This insight should pave the way for pathophysiology-directed therapy, thus contributing to the avoidance of several deleterious effects associated with electrolyte disorders and their treatment.


Keywords


Diabetes, HbA1C, Electrolytes, Anemia.

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About this article

Title

EXPLORING THE INTERRELATIONSHIP BETWEEN ELECTROLYTES, ANEMIA, AND GLYCOSYLATED HEMOGLOBIN (HBA1C) LEVELS IN TYPE 2 DIABETICS

Topics

LABORATORY MEDICINE

Keywords

Diabetes, HbA1C, Electrolytes, Anemia.

DOI

10.22159/ajpcr.2018.v11i1.22533

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 251-256

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

31 Views | 6 Downloads

Authors & Affiliations

Lavanya Rajagopal
SRM Medical College Hospital and Research Centre, Kattankulathur, Chennai 603203 INDIA
India

Vinothkumar Ganesan
SRM Medical College Hospital and Research Centre, Kattankulathur, Chennai 603203 INDIA
India

Saleh Mohammed Abdullah
Jazan University, Jazan, Saudi Arabia.
Saudi Arabia

Sundaram Arunachalam
SRM Medical College Hospital and Research Centre, Kattankulathur, Chennai 603203
India

Kumaresan Kathamuthu
Jazan university, Jazan, Saudi Arabia
Saudi Arabia

Balaji Ramraj
SRM Medical College Hospital and Research Centre, kattanulathur,Chennai India,
India


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