ANTITUMOR POTENTIAL OF HYDROETHANOLIC EXTRACT OF ANNONA MURICATA LEAVES AGAINST DALTONâ€™S LYMPHOMA ASCITES-INDUCED TUMOR IN MICE
Â Objective: The objective of this study was to assess the antitumor activity of hydroethanolic extract of Annona muricata (HEEAM) in Daltonâ€™s lymphoma ascites (DLA)-induced tumor model.
Methods: Antitumor activity of HEEAM was evaluated against DLA-induced tumor mice by assessing the antitumor, hematological, and biochemical parameters.
Results: The results revealed that antitumor activity of HEEAM was observed in Swiss albino mice at the doses of 200 and 400 mg/kg body weight given orally for 15 days. The results indicated that administration of the extracts not only increased the survival of animals and decreased the body weight with ascites tumor but also altered many hematological and biochemical parameters. Both extracts exhibited a significant (p<0.05) antitumor activity on dose-dependent manner. Among the two doses, 400 mg/kg of HEEAM dose showed potent anticancer activity.
Conclusion: The findings confirmed that the HEEAM possess potent antitumor activity, and hence, it might be used as a natural anticancer agent
2. Krishnaveni M, Mirunalini S. Amla-The role of ayurveda therapeutic herb in cancer. Asian J Pharm Clin Res 2011;4:13-7.
3. Kliensmith LJ. Principles of Cancer Biology. 4th ed. San Francisco, CA: Pearson Benjamin Cummings in San Fransisco; 2007. p. 312.
4. Mohan RN, Rajashekhar RN, Kaiser J. Spicy anti-cancer spices: A review. Int J Pharm Pharm Sci 2015;7:1-6.
5. Haldar PK, Bhattacharya S, Kar B, Bala A, Mazumder UK. Chemoprventive role of Indigofera as palathoides in 20-methylcholanthrene induced carcinogenesis in mouse. Toxicol Enviro Chem 2010;92:1749-63.
6. Armour FE, Blood FR, Belden DA. The Manual for Laboratory Work in Mammalian Physiology. 3rd ed. Chicago: The University of Chicago; 1965.
7. Morton DB, Griffiths PH. Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. Vet Rec 1985;116:431-6.
8. Sundaresan B, Subbiah M. Antitumor activity of Chondrococcus hornemanni and Spyridia fusiformis on Daltonâ€™s lymphoma ascites in mice. Bangladesh J Pharmacol 2012;7:173-7.
9. Jeena K, Liju VB, Kuttan R. Antitumor and cytotoxic activity of ginger essential oil (Zingiber officinale roscoe). Int J Pharm Pharm Sci 2015;7:341-4.
10. Adhvaryu MR, Reddy N, Parabia MH. Effects of four Indian medicinal herbs on Isoniazid, Rifampicin and Pyrazinamide induced hepatic injury and immunosuppresion in guinea. World J Gastroenterol 2007;13:3199-205.
11. Santoshkumar HD, Shrishailappa B, Ashok G. Antitumor activity of Hypericum Hookerianum against DLA induced tumor in mice and its possible mechanism of action. Phytother Res 2008;22:23-9.
12. Jackson T, Chougule MB, Ichite N, Patlolla RR, Singh M. Antitumour activity of noscapine in human non-small cell lung cancer xenograft model. Cancer J Chemother Pharmacol 2008;63:117-26.
13. Sakthivel KM, Guruvayoorappan C. Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators-(TNF-a, iNOS, COX-2, IL-1AY, IL-6, IFN-I, IL-2, GM-CSF) and pro-angiogenic growth factor-VEGF. Asian Pac J Cancer Prev 2013;14:3909-19.
14. DeWys WD. Pathophysiology of cancer cachexia: Current understanding and areas for future research. Cancer Res 1982;42:721s-726s.
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