STEREOCHEMISTRY - RACEMIC MODIFICATION, RESOLUTION, AND ITS IMPORTANCE WITH RECENTLY USED OPTICALLY ACTIVE DRUGS.


Chetna Baregama

Abstract


 Stereochemistry involves the study of the relative spatial arrangement of atoms that form the structure of molecules and their manipulation. An important branch of stereochemistry is the study of chiral molecules. Optical activity is the ability of a chiral molecule to rotate the plane of plane-polarized light, measured using a polarimeter. Racemic modification and resolution, both processes are very important in stereochemistry. A mixture of equal parts of enantiomers is called a racemic modification. The process of separating a racemate into pure enantiomers is known as resolution. Recently, various optically active drugs are used for the treatment for various diseases. In these drugs, some are used as mixture of enantiomers and some used as single enantiomer. For preparation of optically active drugs, racemic modification and resolution processes are generally used. Hence, this is very important to know about various steps and types of processes used for the same. Racemic modification is advantageous where racemates have more therapeutic advantages than single isomers. Resolution is advantageous where single entiomer is used for treatment because single enantiomers have less complex and more selective pharmacodynamic profile as compared to racemic mixture so have lesser adverse drug reactions, improved therapeutic profile, less chances of drug interactions than racemic mixtures. Recently used optically active drugs are amlodipine, atenolol, cetirizine, ketamine, metoprolol, omeprazole, pantoprazole, salbutamol, propranolol, clopidogrel, rabeprazole, citalopram, ibuprofen, ketoprofen, zopiclone, etodolac, salbutamol, and nateglinide.


Keywords


Stereochemistry, Racemic modification, Resolution, Enantiomers.

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About this article

Title

STEREOCHEMISTRY - RACEMIC MODIFICATION, RESOLUTION, AND ITS IMPORTANCE WITH RECENTLY USED OPTICALLY ACTIVE DRUGS.

Keywords

Stereochemistry, Racemic modification, Resolution, Enantiomers.

DOI

10.22159/ajpcr.2018.v11i1.23090

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 3-12

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

67 Views | 132 Downloads

Authors & Affiliations

Chetna Baregama
Department of Medicinal and Pharmaceutical Chemistry, B. R. Nahata College of Pharmacy, Mandsaur University, Mandsaur, Madhya Pradesh, India.
India


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