ANTIHYPERLIPIDEMIC PROPERTY OF BOERHAVIA DIFFUSA LEAF EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS


Vasundhara Ccs, Gayathri Devi S

Abstract


 Objectives: The aim of the present research was to evaluate the antidiabetic, hyperlipidemic, and histopathological analysis in streptozotocin-induced diabetic rats (60 mg/kg body weight) using the ethanolic extract of leaves of Boerhavia diffusa (ELBD) (500 mg/kg body weight).

Method: The rats were orally administered with the leaf extract for 45 days. Fasting blood was collected at the end of the experimental period by cardiac puncture to carry out the biochemical parameters, the organs such as liver, kidney, and pancreas were also excised to perform the histopathological analysis by fixing in 10% formalin solution.

Results: Oral administration with the leaf extract resulted in decrease in the levels of blood glucose, with a concomitant increase in their body weight. The extracts also produced a significant decrease in the lipid levels when compared with the diabetic groups. Moreover, the extracts also exerted a favorable effect on the histopathological changes of liver, pancreas, and kidney.

Conclusion: The results of the present study revealed that the ELBD possess antidiabetic and antihyperlipidemic properties. These effects may be due to the presence of bioactive components justifying its ethnomedical use.


Keywords


Streptozotocin, Anti-inflammatory, Antidiabetic, Histopathological.

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About this article

Title

ANTIHYPERLIPIDEMIC PROPERTY OF BOERHAVIA DIFFUSA LEAF EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Keywords

Streptozotocin, Anti-inflammatory, Antidiabetic, Histopathological.

DOI

10.22159/ajpcr.2018.v11i4.23226

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 4 April 2018 Page: 173-176

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Vasundhara Ccs
Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore – 641 043, Tamil Nadu, India.
India

Gayathri Devi S
Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore – 641 043, Tamil Nadu, India.
India


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