• Shubhi Rastogi Amity Research Cell, Amity University Uttar Pradesh, Lucknow Campus, India
  • Mohammed Shariq Iqbal Amity Research Cell, Amity University Uttar Pradesh, Lucknow Campus, India
  • Deepak Ohri Amity Research Cell, Amity University Uttar Pradesh, Lucknow Campus, India


 Objective: The objective of the present work is to study the in vitro anti-inflammatory and antioxidant activity of medicinal plants. The extent and correlation between anti-inflammatory and antioxidant activity have been studied.

Method: Methanolic and aqueous extracts of five medicinal plants, namely, Ficus racemosa, Aloe vera, Cannabis sativa, Datura stramonium, and Calotropis gigantean have been taken for in vitro anti-inflammatory and total antioxidant activity.

Result: The study showed that the inhibition of protein (albumin) denaturation was maximum in aqueous extract of A. vera with 97.55±1.45%. Proteinase inhibitory action of different plant extracts showed significant action and was found to be maximum in aqueous extract of D. stramonium with 87.89±2.58%. Heat-induced hemolysis showed that maximum inhibition was with aqueous extract of F. racemosa with 90.72±3.33%. When hypotonicity-induced hemolysis activity was done it was found maximum in methanolic extract of C. gigantea with 90.58±3.04%. Anti-lipoxygenase activity was found maximum in methanolic extract of F. racemosa with 94.05±4.24%. When total antioxidant activity was done, it was found highest in F. racemosa (4.38±0.546 mM equivalent of ascorbic acid/g tissue).

Conclusion: An overall strong positive correlation between anti-inflammatory and antioxidant activity was observed, indicating that antioxidant activity of the plant species studied might be responsible for their anti-inflammatory property. Further work needs to be undertaken to fully elucidate the antioxidants responsible for anti-inflammatory action and to develop better herbal drug formulations.

Keywords: Pharmacology

Author Biographies

Shubhi Rastogi, Amity Research Cell, Amity University Uttar Pradesh, Lucknow Campus, India
Research Scholar
Mohammed Shariq Iqbal, Amity Research Cell, Amity University Uttar Pradesh, Lucknow Campus, India
Administrator Research
Deepak Ohri, Amity Research Cell, Amity University Uttar Pradesh, Lucknow Campus, India
Deputy Dean Research


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How to Cite
Rastogi, S., M. Iqbal, and D. Ohri. “IN VITRO STUDY OF ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF SOME MEDICINAL PLANTS AND THEIR INTERRELATIONSHIP”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 4, Apr. 2018, pp. 195-02, doi:10.22159/ajpcr.2018.v11i4.23583.
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