ANTIDIABETIC ACTIVITY OF SENNA SURATTENSIS IN ALLOXAN-INDUCED DIABETIC RATS


Ellappan Thilagam, Kumarappan Chidambaram, Subhash Chandra Mandal

Abstract


 Objective: Senna surattensis is a shrub plant which has been known for its diverse biological and pharmacological properties. This study is aimed to evaluate the antidiabetic activity of ethanolic extracts of S. surattensis (EESS) leaves in alloxan-induced diabetic rats.

Methods: Experimental diabetes was induced by injection of a single dose of alloxan (120 mg/kg, intraperitoneal). Adult male Wistar albino rats were divided into five groups; normal control, diabetic control, diabetic EESS (200 mg/kg body weight (bw), diabetic EESS (400 mg/kg bw), and diabetic glibenclamide (5 mg/kg bw). Extracts were treated concurrently for 21 days. Blood samples were collected and centrifuged for estimation of fasting blood glucose (FBG), bw, serum biomarkers, lipid profile, total protein, albumin, and glycosylated hemoglobin (HbA1C) contents.

Results: The increase in FBG, bw, liver biomarkers serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase, free fatty acid, phospholipids (PL), triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total protein, albumin, and HbA1C content were recorded in diabetic control rats. Daily oral administration of EESS treatment significantly (p<0.01) reverted the levels of serum biomarkers and enzymes activities to near normal values. A similar reduction was produced in FBG after 21 days of extract administration which compared significantly (p<0.01) with the control group and glibenclamide treated groups.

Conclusion: The results suggest that EESS has anti-diabetic activity in diabetic rats, thereby justifying its traditional claim and augmenting it into the present system of medicine.


Keywords


Senna surattensis, Alloxan, Hyperglycemia, Diabetes mellitus, Hypolipidemic.

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About this article

Title

ANTIDIABETIC ACTIVITY OF SENNA SURATTENSIS IN ALLOXAN-INDUCED DIABETIC RATS

Topics

Pharmacology

Keywords

Senna surattensis, Alloxan, Hyperglycemia, Diabetes mellitus, Hypolipidemic.

DOI

10.22159/ajpcr.2018.v11i4.23632

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 4 April 2018 Page: 160-163

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

54 Views | 100 Downloads

Authors & Affiliations

Ellappan Thilagam
Department of Pharmaceutical Technology, Pharmacognosy and Phytotherapy Laboratory, Jadavpur University, Kolkata, West Bengal, India.
India

Kumarappan Chidambaram
Department of Pharmacology and Toxicology, School of Pharmacy, King Khalid University, Saudi Arabia.
Saudi Arabia

Subhash Chandra Mandal
Department of Pharmaceutical Technology, Pharmacognosy and Phytotherapy Laboratory, Jadavpur University, Kolkata, West Bengal, India.
India


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