• Ellappan Thilagam Department of Pharmaceutical Technology, Pharmacognosy and Phytotherapy Laboratory, Jadavpur University, Kolkata, West Bengal, India.
  • Kumarappan Chidambaram Department of Pharmacology and Toxicology, School of Pharmacy, King Khalid University, Saudi Arabia.
  • Subhash Chandra Mandal Department of Pharmaceutical Technology, Pharmacognosy and Phytotherapy Laboratory, Jadavpur University, Kolkata, West Bengal, India.


 Objective: Senna surattensis is a shrub plant which has been known for its diverse biological and pharmacological properties. This study is aimed to evaluate the antidiabetic activity of ethanolic extracts of S. surattensis (EESS) leaves in alloxan-induced diabetic rats.

Methods: Experimental diabetes was induced by injection of a single dose of alloxan (120 mg/kg, intraperitoneal). Adult male Wistar albino rats were divided into five groups; normal control, diabetic control, diabetic EESS (200 mg/kg body weight (bw), diabetic EESS (400 mg/kg bw), and diabetic glibenclamide (5 mg/kg bw). Extracts were treated concurrently for 21 days. Blood samples were collected and centrifuged for estimation of fasting blood glucose (FBG), bw, serum biomarkers, lipid profile, total protein, albumin, and glycosylated hemoglobin (HbA1C) contents.

Results: The increase in FBG, bw, liver biomarkers serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase, free fatty acid, phospholipids (PL), triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total protein, albumin, and HbA1C content were recorded in diabetic control rats. Daily oral administration of EESS treatment significantly (p<0.01) reverted the levels of serum biomarkers and enzymes activities to near normal values. A similar reduction was produced in FBG after 21 days of extract administration which compared significantly (p<0.01) with the control group and glibenclamide treated groups.

Conclusion: The results suggest that EESS has anti-diabetic activity in diabetic rats, thereby justifying its traditional claim and augmenting it into the present system of medicine.

Keywords: Senna surattensis, Alloxan, Hyperglycemia, Diabetes mellitus, Hypolipidemic.


1. Sharma S, Chaturvedi M, Edwin E, Sagrawat H. Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis. Int J Diab Dev 2007;27:57-9.
2. Rakesh KV, Vats RK, Kumar V, Abhishek K, Alka M, Uma R. Emerging targets for diabetes. Curr Sci 2003;88:241-9.
3. Zhang BB, Moller DE. New approaches in the treatment of Type 2 diabetes. Curr Opin Chem Biol 2000;4:461-7.
4. Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 2005;59:365-73.
5. Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 2006;13:624-9.
6. Singh V. Monograph on Indian Subtribe Cassiinae (Caesalpinaceae). New Delhi: Pawankumar Scientific Publisher; 2001. p. 215-9.
7. Tripathi YC, Pratibha S, Devesh T. Phytochemical evaluation and antihyperglycemic effects of Elaeocarpus ganitrus roxb (Rudraksha) in streptozotocin-induced diabetes. Int J Pharm Pharm Sci 2015;7:280-3.
8. Irfan AK, Atiya K. Herbal Medicine for Diseases. Germany: India Lambert Academic Publications; 2005.
9. Petchi RR, Vijaya C, Devika GS. Evaluation of the anti-diabetic activity of Cassia surattensis Burm. Flower in streptozotocin-induced diabetic rats. Int J Res Pharm Sci 2012;2:200-5.
10. El-Sawi SA, Sleem AA. Antihyperlipidemic, antihyperglycemic and chemical composition of Senna surattensis (Burm.f.) leaves. Can J Pure Appl Sci 2009;3:779-85.
11. El-Sawi SA, Sleem AA. Flavonoids and hepatoprotective activity of leaves of Senna surattensis (Burm.f.) in CCl4 induced hepatotoxicity in rats. Can J Pure Appl Sci 2009;3:779-85.
12. Sangetha SN, Zuraini Z, Sasidharan S, Suryani S. Antimicrobial activities of Cassia surattensis and Cassia fistula. J Mol Biol Biotechnol 2008;1:1-4.
13. Sangethaa S, Sasidharanb S, Zurainia Z, Suryania S. Antioxidant activity of methanolic extracts of Cassia surattensis. Pharmacologyonline 2008;2:829-38.
14. Ellappan T, Parimaladevi B, Kumarappan C, Mandal SC. α-glucosidase and α-amylase inhibitory activity of Senna surattensis. J Acupunct Meridian Stud 2013;6:24-30.
15. Evans, WC. Trease and Evans Pharmacognosy. 15th ed. London: W.B. Sanders; 2002. p. 183-393.
16. Kumarappan CT, Nageswara RT, Mandal SC. Polyphenolic extract of Ichnocarpus frutescens modifies hyperlipidemia status in diabetic rats. J Cell Mol Biol 2007;6:175-87.
17. Sumathy V, Zakaria Z, Sasidharan S. In vivo toxicity study of Cassia surattensis flower extract. Res J Pharm Biol Chem Sci 2001;2:607-17.
18. Kumar US, Chen Y, Kanwar JR, Sasidharan S. Redox control of antioxidant and antihepatotoxic activities of Cassia surattensis seed extract against paracetamol intoxication in mice: In vitro and in vivo studies of herbal green antioxidant. Oxid Med Cell Longev 2016;2016:6841348.
19. Lenzen S. The mechanisms of alloxan-and streptozotocin-induced diabetes. Diabetologia 2008;51:216-26.
20. Okoro IO, Umar IA, Atawodi SE, Anigo KM. In vitro and in vivo antihyperglycemic effect of an active fraction of Cleome rutidosperma DC. Int J Pharm Pharm Sci 2015;7:289-95.
21. Meghrani M, Lemhadri A, Zeggagh NA, El Amraoui M, Halou M, Jouad H, et al. Effects of an aqueous extract of Triticum repens on lipid metabolism in normal and recent-onset diabetic rats. J Ethnopharmacol 2004;90:331-7.
22. Lemhadri A, Hajji L, Miche, JB, Eddouks M. Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol 2006;106:321-6.
23. Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR, et al. Meta-analysis: Glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 2004;141:421-31.
24. Saddala RR, Lavanya T, Kesireddy SR. Dosage response of Pimpinella tirupatiensis tuberous root extract on the hyperglycemic condition in stzinduced diabetic rats with references to short and long-term treatment. Int J Pharm Pharm Sci 2015;7:389-92.
25. Mahendran S, Badami S, Maithili V. Evaluation of antidiabetic effect of embelin from embelia tribes in alloxan-induced diabetes in rats. Biomed Pharmacother 2010;1:25-31.
26. Balamurugan M, Parthasarathi K, Ranganathan LS, Cooper EL. Hypothetical mode of action of earthworm extract with hepatoprotective and antioxidant properties. J Zhejiang Univ Sci B 2008;9:141-7.
27. Reddi TV, Naidu BV. Ethnomedicine and Human Welfare. India: Lambert Academic Publications; 2005. p. 53.
376 Views | 284 Downloads
How to Cite
Thilagam, E., K. Chidambaram, and S. C. Mandal. “ANTIDIABETIC ACTIVITY OF SENNA SURATTENSIS IN ALLOXAN-INDUCED DIABETIC RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 4, Apr. 2018, pp. 160-3, doi:10.22159/ajpcr.2018.v11i4.23632.
Original Article(s)