A CLINICAL STUDY ON MANAGEMENT OF POST-OPERATIVE PAIN AND QUALITY OF LIFE OF OSTEOARTHRITIS PATIENTS AFTER TOTAL KNEE ARTHROPLASTY


Tamilslevan T, Kalaivani H

Abstract


 Objective: The objective of this study is to assess the effect of pregabalin in the management of post-operative pain and the quality of life (QOL) of osteoarthritis (OA) patients after total knee arthroplasty.

Methods: This prospective observational study was conducted in the Department of Orthopedics. A total of 96 patients were divided into two groups. Group A consists of 50 patients with the treatment of nonsteroidal anti-inflammatory drugs (NSAIDs) and Group B consists of 46 patients with the treatment of pregabalin with NSAIDs. The study subjects were followed once in 60 days for 6 months, and they were asked to answer the visual analog scale (VAS) and knee injury and OA outcome score (KOOS) questionnaire. The effect of the treatment was assessed by comparing the baseline score with follow-up score.

Results: Our study result showed that the pain score of Group B in VAS at 2nd follow-up was 2.56±0.34 and KOOS pain score was 92.73±3.45 (p<0.01). The QOL score was improved significantly to 81.56±5.29 (p<0.01) as compared to Group A.

Conclusion: The study concluded that pregabalin with NSAIDs group patients showed a better improvement in pain, symptoms, and QOL within short duration as compared to NSAIDs alone used group.


Keywords


Osteoarthritis, Total knee arthroplasty, Pregabalin, Nonsteroidal anti-inflammatory drugs, Visual analog scale.

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References


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About this article

Title

A CLINICAL STUDY ON MANAGEMENT OF POST-OPERATIVE PAIN AND QUALITY OF LIFE OF OSTEOARTHRITIS PATIENTS AFTER TOTAL KNEE ARTHROPLASTY

Keywords

Osteoarthritis, Total knee arthroplasty, Pregabalin, Nonsteroidal anti-inflammatory drugs, Visual analog scale.

DOI

10.22159/ajpcr.2018.v11i4.23768

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 4 April 2018 Page: 93-95

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

57 Views | 92 Downloads

Authors & Affiliations

Tamilslevan T
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamil Nadu,
India

Kalaivani H
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamil Nadu,
India


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