EVALUATION OF IN VITRO ANTIDIABETIC AND ANTIOXIDANT POTENTIAL OF BARLERIA CRISTATA LEAVES EXTRACTS


Sakthivel Vasanth, Giridharan Bupesh, Tharumasivam Siva Vijayakumar, Vellingiri Balachandar, Durai Rajan Gunasekaran

Abstract


 Objectives: The objectives of the study were to study the in vitro antidiabetic and antioxidant activity of Barleria cristata leaves extracts.

Methods: Ethanol extract and petroleum ether extract of leaf and root of B. cristata were tested for their antidiabetic activity. The in vitro antidiabetic activity from α-amylase, α-glucosidase, and antioxidant activity was used to assess the potential activity of the fractions.

Results: Our attempt results suggest that ethanol and the petroleum ether leaf extract from B. cristata show signs of dose-dependent increases to inhibitory activity on α-amylase, α-glucosidase enzymes, and antioxidant activity when compared with control. Ethanolic leaves to extract produced maximum in vitro antidiabetic effect and antioxidant activity when compared to petroleum ether extract.

Conclusion: The ethanol leaf extract from B. cristata may be used in managing of blood glucose in a medical condition like diabetes.


Keywords


Barleria cristata, Ethanol extract, Petroleum ether extract, Antidiabetic activity, Antioxidant activity, In vitro study.

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About this article

Title

EVALUATION OF IN VITRO ANTIDIABETIC AND ANTIOXIDANT POTENTIAL OF BARLERIA CRISTATA LEAVES EXTRACTS

Keywords

Barleria cristata, Ethanol extract, Petroleum ether extract, Antidiabetic activity, Antioxidant activity, In vitro study.

DOI

10.22159/ajpcr.2018.v11i4.24069

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 4 April 2018 Page: 287-290

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Sakthivel Vasanth
R and D Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
India

Giridharan Bupesh
R and D Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
India

Tharumasivam Siva Vijayakumar
Department of Biotechnology, Srimad Andavan College of Arts and Science, Tiruchirappalli, Tamil Nadu, India.
India

Vellingiri Balachandar
Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India.
India

Durai Rajan Gunasekaran
R and D Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
India


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