• ANDRE MAROLOP PANGIHUTAN SIAHAAN Department of Neurosurgery, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia.
  • SARMA LUMBANRAJA Department of Obstetrics and Gynaecology, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia.


Objective: Traumatic brain injury (TBI) is one of the major health problems regarding morbidity and mortality, especially in productive ages. Following primary injury, there is a secondary insult, resulting in oxidative stress, neuroinflammation, and cell death. Mangosteen is a powerful natural antioxidant and anti-inflammation that also has neuroprotective property. The aim of this study was to explore the effect of mangosteen extract (ME)on neuroinflammation following TBI.

Methods: A total of 30 Sprague-Dawley rats were randomized into three treatments group, i.e., sham-operated controls, closed head injury (CHI), and treatment group. In the treatment group, we gave ME once daily every day after CHI for 7 days. As oxidative process marker, we investigated malondialdehyde (MDA) expression. As neuroinflammation marker, we investigated glial fibrillary acidic protein (GFAP) and CD-68.

Results: TBI increased the expression of GFAP and CD-68, but not MDA. There was significant GFAP expression difference between treatment group and CHI group. Regarding the expression of CD-68 and MDA, there was no significant difference between treatment and CHI group.

Conclusion: Mangosteen extract supplementation decreased GFAP expression significantly after TBI.

Keywords: Mangosteen extract, Traumatic brain injury, Neuroinflammation.

Author Biography

ANDRE MAROLOP PANGIHUTAN SIAHAAN, Department of Neurosurgery, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia.

Staff in Department of Neurosurgery



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How to Cite
PANGIHUTAN SIAHAAN, A. M., and S. LUMBANRAJA. “EFFECT OF MANGOSTEEN EXTRACT ON NEUROINFLAMMATION IN RAT MODEL OF ACUTE TRAUMATIC BRAIN INJURY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 3, Feb. 2019, pp. 61-63, https://innovareacademics.in/journals/index.php/ajpcr/article/view/24267.
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