• Priyankar Dey University of North Bengal
  • Manas Ranjan Saha University of North Bengal
  • Arnab Sen University of North Bengal


Liver is a vital organ, contributing in most of the metabolic and physiological processes of our body. It plays principal role in detoxification of various drugs and xenobiotics. Though liver possess tremendous regenerative capacity, but metabolism of various chemicals severely damage the hepatic system. Drug induced hepatotoxicity (DIHT) is a major concern in this respect. The drugs we consume to treat various diseases, very often, their metabolic intermediates cause liver toxicity. The lion's share of the idiosyncratic drug reactions ultimately results either in liver transplantation or even death. DIHT is a major medical concern at present and several drugs have been withdrawn from the market due to their hepatotoxic phenotype. Therefore, considering the phenomenon of DIHT, we have documented various aspects of DIHT, also discussing about the mode of toxicity of the drugs.


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Author Biographies

Priyankar Dey, University of North Bengal


Dept. of Zoology

Manas Ranjan Saha, University of North Bengal

Dept. of Botany

Arnab Sen, University of North Bengal

Dept. of Botany


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How to Cite

Dey, P., M. R. Saha, and A. Sen. “AN OVERVIEW ON DRUG-INDUCED HEPATOTOXICITY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 4, Oct. 2013, pp. 1-4,