• Lalithamma A Department of Physiology, Bharath University, Chennai, Tamil Nadu, India.
  • Vadivel S Department of Physiology, Karpaga Vinayaga Institute of Medical Sciences, Chennai, Tamil Nadu, India.
  • Johnson W Department of Anatomy, Sree Balaji Medical College and Research Centre, Chennai, Tamil Nadu, India.
  • Jacob V Department of Pharmacology, Karpaga Vinayaga Institute of Medical Sciences, Chennai, Tamil Nadu, India.
  • Chitra T Department of Pathology, Karpaga Vinayaga Institute of Medical Sciences, Chennai, Tamil Nadu, India.




Hypothyroidism, Motor nerve conduction, Sensory nerve conduction, Median nerve, ulnar nerve, Thyroid-stimulating hormone


Objective: This observational study was conducted during the year 2016–2017 to assess the electrodiagnostic evidence of peripheral nerve dysfunction among newly diagnosed hypothyroid patients attending a tertiary care hospital and to find the effect of hormonal treatment after short duration.

Methods: An observational study was conducted in 25 newly diagnosed hypothyroid patients with the age group of 20–60 were included. After obtaining informed consent, all participants were examined with electrodiagnostic workup performed at the initial time of diagnosis and after short duration for median and ulnar nerves of upper limb by (NeuroStim -NS2, EMG/EP/NCV, and MEDICAID SYSTEMS). Electrophysiological parameters such as distal motor latency, amplitude, and conduction velocity were evaluated.

Results: The mean age of study population was 42.7±12.1 (23–61) years. The mean values of nerve conduction velocity of motor and sensory median before the treatment were 42.8±15.7 and 40.13±4.19 and motor and sensory ulnar before treatment were 41.18±22.4 and 39.46±11.9. The mean values of nerve conduction velocity of motor and sensory median after treatment were 53.35±4.7 and 57.3±5.6 and motor and sensory ulnar After treatment were 54.56±2.99 and 54.09±12.17. The result of the study. Shows that there were reduction of conduction velocity before treatment and statistically significant after 3 months duration of treatment with appropriate doses.

Conclusion: After treatment, total triiodothyronine, total thyroxin, free triiodothyronine, free thyroxin, thyroid-stimulating hormone, and median and ulnar nerve motor and sensory functions were normal with appropriate treatment. The involvement of sensory fibers is more than that of the motor fibers.


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Author Biography

Lalithamma A, Department of Physiology, Bharath University, Chennai, Tamil Nadu, India.



Hebbari S, Kumar S, Amin S, Doizode S. Subclinical hypothyroidism in pregnancy; is there a need for pharmacological intervention? Int J Pharm Pharm Sci 2017;9:186-91.

Hall JE, Guyton AC. Textbook of Medical Physiology 12th ed. India: Elsevier Publications; 2013. p. 565-76.

Ganong WF. Review of Medical Physiology. 22nd ed. New York: McGraw Hills Publications; 2005. p. 317.

Ajeena IM. Prevalence of neuromuscular abnormalities in newly diagnosed patients with thyroid dysfunction. Am J Res Commun 2013;1:79-88.

Gupta N, Arora M, Sharma R, Arora KS. Peripheral and central nervous system involvement in recently diagnosed cases of hypothyroidism. an electrophysiological study. Ann Med Health Sci Res 2016;6:261-6.

Duyff RF, Van den Bosch J, Laman DM, van Loon BJP, Linssen WH. Neuromuscular findings in thyroid dysfunction: A prospective clinical and electro diagnostic study. J Neurol Neurosurg Psychiatry 2000;68:750-5.

Parkhad SB, Palve SB, Chandrasekhar MC, Shankari P. Assessment and comparison of electrophysiological findings in thyroid dysfunction patients of Kanchipuram District. Int J Biol Med Res 2015;6:5068-71.

Sankareswari A, Shreen LA, Vigil TD, Naveen S, Chandrasekhar M. Evaluation of peripheral nerve conduction and visual evoked potential in newly diagnosed hypothyroid females. Int J Med Res Health Sci 2016;5:43-6.

Kumar PR, Kalshetti SM, Bhatt JK. Supplementation of a-lipoic acid in diabetic peripheral neuropathy. A Prospective open label randomized controlled trial. Int J Pharm Pharm Sci 2014;6:90-3.

Nemni R, Bottacchi E, Fazio R, Mamoli A, Corbo M, Camerlingo M, et al. Polyneuropathy in hypothyroidism: Clinical, electrophysiological and morphological findings in four cases. J Neurol Neurosurg Psychiatry 1987;50:1454-60.

Khedr EM, El-Toony LF, Tarkhan MN, Abdella G. Peripheral and central nervous system alterations in hypothyroidism: Electrophysiological findings. Neuropsychobiology 2000;41:88-94.

Eslamian F, Bahrami A, Aghamohammadzadeh N, Niafar M, Salekzamani Y, Behkamrad K. Electrophysiological changes in patients with untreated primary hypothyroidism. J Clin Neurophysiol 2011;28:323-8.

Lai CL, Liu CK, Tai CT, Lin RT, Howng SL. A study of central and peripheral nerve conduction in patients with primary hypothyroidism: The effects of thyroxin replacement. Kaohsiung J Med Sci 1998;14:294-302.

Kececi H, Degirmenci Y. Hormone replacement therapy in hypothyroidism and nerve conduction study. Neurophysiol Clin 2006;36:79-83.

El-Salem K, Ammani F. Neurophysiological changes in neurologically asymptomatic hypothyroid patients: A prospective cohort study. J ClinNeurophysiol 2006;23:568-72.

Mishra UK, Kalitha J. Text Book of Clinical Neurophysiology. 2nd ed. New Delhi: MBD Publishers; 2005.

Kedlaya D. Loma. Hypothyroid Myopathy. Linda, CA: Loma Linda University School of Medicine, Updated; 2007.

Gabriel Bucurescu, Thyroid Diseases 2006.

Abbott RJ, O’Malley BP, Barnett DB. Central and peripheral nerve conduction in thyroid dysfunction: The influence of L-thyroxin therapy compared with warming upon the conduction abnormalities of primary hypothyroidism. Clin Sci (Lond) 1988;64:617-22.

Adikesavan B, Gowdhaman N, Rao BV, Balasubramanian K. A study of nerve conduction velocity in newly diagnosed hypothyroid females. World J Med Sci 2013;9:198-201.

Yuksel G, Karlikaya G, Tanridag T, Us O, Akyuz G. Nerve conduction studies, SEP and blink reflex studies in recently diagnosed, untreated thyroid disease patients. J Neurol Sci (Turkish) 2007;24:7-15.

Jalilzadeh SH, Bahrami A, Eftekharosadat B, Mobasseri M, Pezeshki Z. Peripheral nerve function in subclinical hypothyroidism: A case-control study. Int J Endocrinol Metab 2006;4:78-83.

Yeasmin S, Begum N, Begum S. Motor neuropathy in hypothyroidism: Clinical and electrophysiological findings. BSMMU J 2008;1:15-8.



How to Cite

A, L., V. S, J. W, J. V, and C. T. “EFFECT OF NERVE CONDUCTION STUDIES IN HYPOTHYROIDISM - AN OBSERVATIONAL STUDY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 8, Aug. 2018, pp. 326-9, doi:10.22159/ajpcr.2018.v11i8.25696.



Original Article(s)