ANTICANCER ACTIVITY OF ZINC OXIDE AND ZINC OXIDE/CADMIUM SULFIDE NANOCOMPOSITES

  • ALI JABBAR JASIM MAKKAWI Department of Chemistry, Directorate of Education in Babylon, Ministry of Education, Iraq.
  • NOOR HADI AYSA Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Iraq.
  • FATTIMA-ALZAHRA G GASSIM Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Iraq.

Abstract

Objective: The objective of this study is to investigate the anticancer activity of zinc oxide (ZnO) and ZnO/cadmium sulfide (CdS) nanoparticles (NPs). These NPs were active index against five human tumor cell lines, namely hepatocellular carcinoma, mammary gland (MCF-7), epidermoid carcinoma (HEP2), colorectal carcinoma (HCT-116), and rhabdomyosarcoma (RD).


Methods: ZnO and ZnO/CdS NPs were synthesized using zinc acetate dihydrate and oxalic acid. The samples are characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force microscopy (AFM).


Results: The results were indicated that these NPs can be used to made drug delivery system depending on ZnO and ZnO/CdS nanocomposites for its potential role in enhancing the anticancer efficacy of doxorubicin as well as work on reducing side effects.


Conclusions: ZnO and ZnO/CdS nanocomposites can be used anticancer for five human tumor cells.

Keywords: Medical applications of nanocomposites, Antitumor activity, Antioxidant activity.

References

1. Jeong YI, Kim DH, Chung CW, Yoo JJ, Choi KH, Kim CH, et al. Doxorubicin-incorporated polymeric micelles composed of dextran-b-poly(DL-lactide-co-glycolide) copolymer. Int J Nanomedicine 2011;6:1415-27.
2. Zheng J, Lee HC, Bin Sattar MM, Huang Y, Bian JS. Cardioprotective effects of epigallocatechin-3-gallate against doxorubicin-induced cardiomyocyte injury. Eur J Pharmacol 2011;652:82-8.
3. Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, et al. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2008;2:889-96.
4. Selvakumari D, Deepa R, Mahalakshmi V, Subhashini P, Lakshminarayan N. Anticancer activity of ZnO nanoparticles on MCF7 (breast cancer cell) and A549 (cancer cell). ARPN J Eng Appl Sci 2015;10:5418-21.
5. Yousefpour P, Atyabi F, Farahani EV, Sakhtianchi R, Dinarvand R. Polyanionic carbohydrate doxorubicin-dextran nanocomplex as a delivery system for anticancer drugs: In vitro analysis and evaluations. Int J Nanomedicine 2011;6:1487-96.
6. Ibsen S, Zahavy E, Wrasdilo W, Berns M, Chan M, Esener S, et al. A novel doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy. Pharm Res 2010;27:1848-60.
7. Chahal A, Saini AK, Kumar A, Saini RV. Natural antioxidants as defense against cancer. Asian J Pharm Res 2018;11:38-44.
8. Mishra PK, Mishra H, Ekielski A, Talegaonkar S, Vaidya B. Zinc oxide nanoparticles: A promising nanomaterial for biomedical applications. Drug Discov Today 2017;22:1825-34.
9. Guo D, Wu C, Jiang H, Li Q, Wang X, Chen B, et al. Synergistic cytotoxic effect of different sized znO nanoparticles and daunorubicin against leukemia cancer cells under UV irradiation. J Photochem Photobiol B 2008;93:119-26.
10. Wang H, Wingett D, Engelhard MH, Feris K, Reddy KM, Turner P, et al. Fluorescent dye encapsulated znO particles with cell-specific toxicity for potential use in biomedical applications. J Mater Sci Mater Med 2009;20:11-22.
11. Yadav V. Nanotechnology, big things from a tiny world: A review. Int J Serv Sci Technol 2013;3:771-8.
12. Lin W, Xu Y, Huang CC, Ma Y, Shannon KB, Chen DR, et al. Toxicity of nano-and micro-sized ZnO particles in human lung epithelial cells. J Nanopart Res 2009;11:25-39.
13. Arakelova ER, Grigoryan SG, Arsenyan FG, Babayan NS, Grigoryan RM, Sarkisyan NK. In vitro and in vivo anticancer activity of nanosize zinc oxide composites of doxorubicin. Int J Biomed Pharm Sci 2014;8:1.
14. Litter ML, Navio JA. Un usual photo reactivity of zinc oxide irradiated by concentrated sun light. J Photochem Photobiol A Chem 1994;79:131.
15. Chica A, Gatti G, Moden B, Marchese L, Iglesia E. Selective catalytic oxidation of organosulfur compounds with tert-butyl hydroperoxide. Chemistry 2006;12:1960-7.
16. Xin JH, Yeo SY, Lee HJ, Jeong SH. Preparation of nano composite fibres for permanent antibacterial effect. J Mater Sci 2003;38:2143-7.
17. Gnanasangeetha D, Thambwani DS. Biogenic production of zinc oxide nanoparticlesusing Acalypha indica. J Chem Biol Phys Sci 2013;1:238-46.
18. Spolenak R, Ludwig W, Buffiere JY, Michler J. In-situ elastic strain measurements-diffraction and spectroscopy. MRS Bull 2010;35:368-74.
19. Zhang F, Yang J. Preparation of nano-ZnO and its application to the textile on antistatic finishing. Int J Chem 2009;1:18-22.
20. Rasal S, More PV, Hiragond C, Jadhav S, Khanna PK. Rapid homogenization method for synthesis of core/shell ZnO/CdS nanoparticles and their photocatalytic evaluation. Adv Mater Lett 2016;7:390-7.
21. Kahn ML, Monge M. Size-and shape-control of crystalline zinc oxide nanoparticles: A new organometallic synthetic method. Adv Funct Mater 2005;3:458-68.
22. Kavithar R. Antidiabetic and enzymatic antioxidant potential from ethanolic extracts of leaf and fruit of Trichosanthes dioica and leaf of Clitoria ternatea on diabetic rats induced by streptozotocin. Asian J Pharm Clin Res 2018;11:233-9.
23. El-Gazar A, Adams B, Youssef YM, Abu-Hashem AA, Badria FA. Design and synthesis of azolopyrimidoquinolines, pyrimidoquinazolines as anti-oxidant, anti-inflammatory and analgesic activities. J Med Chem 2009;44:609-24.
24. Aeschlach R, Loliger J, Scott CB, Murcia A, Butler JB, Halliwell IO. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol 1994;32:31-6.
25. Pal S, Tak YK, Song JM. Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the gram-negative bacterium Escherichia coli. Appl Environ Microbiol 2007;73:1712-20.
26. Huang K, Ma H, Liu J, Huo S, Kumar A, Wei T, et al. Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo. ACS Nano 2012;6:4483-93.
27. Rasmussen JW, Martinez E, Louka P, Wingett DG. Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert Opin Drug Deliv 2010;7:1063-77.
28. AL-Zahra AF, Alkhateeb A, Hussin F. Photocatalytic oxidation of benzyl alcohol using pure and sensitized anatase. Desalination 2007;209:342-9.
29. AL-Zahra AF, Azize HW, Jassim AJ. Sterilization of waste water from Staphylococcus aureaus bacteria by using TiO2. Int J Chem 2013;2:386-91.
30. Arya P. Antioxidant, phytochemical and antibacterial action of Himalayan medicinal herbs Peristrophe bicalyculata leaves extract against respiratory tract pathogens. Int J Pharm Pharm Sci 2018;10:16-21.
31. Lissi E, Modak B, Torres R, Escobar J, Urza A. Total antioxidant potential of resinous exudates from Heliotropium species, and a comparison of the ABTS and DPPH methods, Free Radic Res 1999;30:471-7.
32. Shaaban S, Negm A, Sobh MA, Wessjohann LA. Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation. Eur J Med Chem 2015;97:190-201.
33. Barathmanikanth S, Kalishwaralal K, Sriram M, Pandian SR, Youn HS, Eom S, et al. Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice. J Nanobiotechnology 2010;8:16.
34. Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 2004;56:1649-59.
35. Shaji J, Shaikh M. Drug-resistant tuberculosis: Recent approach in polymer based nanomedicine resistant tuberculosis. Int J Pharm Pharm Sci 2016;8:1-6.
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JASIM MAKKAWI, A. J., N. H. AYSA, and F.-A. G GASSIM. “ANTICANCER ACTIVITY OF ZINC OXIDE AND ZINC OXIDE/CADMIUM SULFIDE NANOCOMPOSITES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 535-9, https://innovareacademics.in/journals/index.php/ajpcr/article/view/26265.
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