• ALI JABBAR JASIM MAKKAWI Department of Chemistry, Directorate of Education in Babylon, Ministry of Education, Iraq.
  • NOOR HADI AYSA Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Iraq.
  • FATTIMA-ALZAHRA G GASSIM Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Iraq.


Objective: The objective of this study is to investigate the anticancer activity of zinc oxide (ZnO) and ZnO/cadmium sulfide (CdS) nanoparticles (NPs). These NPs were active index against five human tumor cell lines, namely hepatocellular carcinoma, mammary gland (MCF-7), epidermoid carcinoma (HEP2), colorectal carcinoma (HCT-116), and rhabdomyosarcoma (RD).

Methods: ZnO and ZnO/CdS NPs were synthesized using zinc acetate dihydrate and oxalic acid. The samples are characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force microscopy (AFM).

Results: The results were indicated that these NPs can be used to made drug delivery system depending on ZnO and ZnO/CdS nanocomposites for its potential role in enhancing the anticancer efficacy of doxorubicin as well as work on reducing side effects.

Conclusions: ZnO and ZnO/CdS nanocomposites can be used anticancer for five human tumor cells.

Keywords: Medical applications of nanocomposites, Antitumor activity, Antioxidant activity.


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How to Cite
JASIM MAKKAWI, A. J., N. H. AYSA, and F.-A. G GASSIM. “ANTICANCER ACTIVITY OF ZINC OXIDE AND ZINC OXIDE/CADMIUM SULFIDE NANOCOMPOSITES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 535-9, doi:10.22159/ajpcr.2019.v12i2.26265.
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