STUDIES ON HEPATOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITY OF COIX LACRYMA–JOBI (LINN)

  • Geetha S Department of Biochemistry, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
  • Jannathul Firdous Department of Preclinical, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia.
  • Karpagam T Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, Tamil Nadu, India.
  • Varalakshmi B Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, Tamil Nadu, India.
  • Shanmuga Priya Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, Tamil Nadu, India.
  • Sugunabai J Department of Biochemistry, Seethalakshmi Ramaswami College, Tiruchirappalli, Tamil Nadu, India.
  • Gomathi S Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, Tamil Nadu, India.

Abstract

Objective: In the present study, evaluation of hepatoprotective activity of Coix lacryma-jobi by CCl4-induced hepatotoxicity test, and evaluation of anti-inflammatory activity of by egg albumin-induced paw edema, and complete Freund’s adjuvant-induced arthritis model were done.

Methods: Plant extract was prepared by mixing ethanol with powdered plant seeds and experiment was done as per the procedures of above-mentioned three models.

Results: C. lacryma-jobi test extracts out of two doses, 400 mg/kg exhibited a significant reduction in serum cholesterol level as 33 mg/dl when compared to control groups. C. lacryma-jobi seed extract has restored various serological alterations following CCl4-induced hepatotoxicity and was capable of reversing the toxic effects of CCl4 on liver cells. Considerable reduction in the paw volume of exudates observed with C. lacryma-jobi extract, indicating significant anti-inflammatory activity.

Conclusion: Therefore, this study shows that C. lacryma-jobs seed extract have anti-inflammatory activity in the models studied.

Keywords: Anti-inflammation, Coix lacryma-jobi, Hepatotoxicity, Rheumatoid arthritis, and Edema.

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S, G., J. Firdous, K. T, V. B, S. Priya, S. J, and G. S. “STUDIES ON HEPATOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITY OF COIX LACRYMA–JOBI (LINN)”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 11, Nov. 2018, pp. 290-3, doi:10.22159/ajpcr.2018.v11i11.26307.
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