CARBOPOLÂ®-GUAR GUM GEL AS A VEHICLE FOR TOPICAL GEL FORMULATION OF PECTIN BEADS LOADED WITH RUTIN
Objective: The aim of this study was to develop suitable pharmaceutical gel formulations of pectin beads using semisynthetic celluloses or synthetic carbomers as a gelling agent.
Methods: Low methoxyl pectin (LMP) beads loaded with rutin composing 3% Non-amidated LMP, 15% sorbitol and 1% NaHCO3 with 2% w/v of rutin were prepared, characterized, incorporated in various pharmaceutical gel bases and evaluated for rabbit skin irritation by close patch test.
Results: Rutin wetted bead formulation which showed spherical shape (around 700 Âµm), high rutin encapsulation efficiencies (82.02Â±0.91%), low conductivity (900 ÂµS at 30 min) and faster rutin release (more than 80% in 30 min) was selected to incorporate in gel. The wetted rutin beads exhibited good stability (beads suspended in gel without breaking or gel color changing) in the gel composed of 0.4% w/v CarbopolÂ® Ultrez 21 with 0.04% w/v guar gum at pH 5.0.Â Conclusion: Rutin wetted beads in developed pharmaceutical gel formulation showed higher percentages of rutin remaining when stored at room temperature (27Â±2ÂºC) than non-loaded rutin of about 1.53 times and gave no irritation in rabbit skin irritation test, however, the safety on human skin applications should be confirmed.
ÂKeywords: CarbopolÂ®, guar gum, pharmaceutical gel, pectin, rutin, beads
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