INVESTIGATION AND OPTIMIZATION OF FORMULATION PARAMETERS FOR SELFNANOEMULSIFYING DELIVERY SYSTEM OF TWO LIPOPHILIC AND GASTROINTESTINAL LABILE DRUGS USING BOX-BEHNKEN DESIGN

Authors

  • Bimlesh Kumar School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Varun Garg School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Amarjeet Singh Pharmacovigilance Scientist, Parexel International Services India Pvt. Ltd, Chandigarh, India.
  • Narendra Kumar Pandey Pharmacovigilance Scientist, Parexel International Services India Pvt. Ltd, Chandigarh, India.
  • Saurabh Singh School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Sakshi Panchal School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Indu Melkani School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Raji Raji School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Manzi Axel School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Souvik Mohanta School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Jivan Jyoti School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Sananda Som School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Monica Gulati School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Amit Bhatia Department of Pharmaceutical Science and Technology, MRSPTU, Bathinda, India.
  • Prakash T Department of Physiology and Pharmacology, Acharya and B.M. Reddy College of Pharmacy, Bengaluru, Karnataka, India.
  • Sachin Kumar Singh School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s2.28585

Keywords:

Curcumin, Duloxetine hydrochloride, Binary mixture, Curcumin - duloxetine hydrochloride - self-nanoemulsifying drug delivery systems, Box Behnken design, Castor oil, Nil, Tween-80

Abstract

Objective: Present research work aims toward codelivery of two hydrophobic drugs, curcumin (CRM) and duloxetine hydrochloride (DXH) through self-nanoemulsifying drug delivery systems (SNEDDS).

Methods: Initially, binary mixture in the ratio of 1:1 was prepared and then loaded into SNEDDS. Box-Behnken design (BBD) was adopted to develop SNEDDS. As per the optimal design, 13 SNEDDS prototypes were prepared. Castor oil, tween-80 and Transcutol P® were used as oil, surfactant, and cosurfactant, respectively. To 1 mL of SNEDDS, 30 mg each of CRM and DXH was loaded (CRM-DXH- SNEDDS).

Results: The design revealed that for mean droplet size, polydispersity index (PDI), as well as percentage drug loading, all the three factors, i.e. ratio of oil (a), surfactant (b), and cosurfactant (c) were found to give significant effect. Factor B showed the most significant effect on mean droplet size (y1). In case of PDI (y2), factors B and C exerted maximum influence, whereas, Factor A has shown non-significant effect. For percentage drug loading of drugs (y3 and y4), all the three factors were found to have the most significant effect. The optimized batch of CRM-DXH- SNEDDS having composition castor oil, tween-80, and Transcutol P® in the ratio: 2.17:5.22:2.61, revealed that the mean drug loading (%) of CRM and DXH in an optimized batch of SNEDDS was found to be 87.22±1.87 and 92.32±0.19%, respectively. The mean droplet size, PDI, and zeta potential of formed SNEDDS were observed as 113.14±1.14 nm, 0.20±0.026, and −13.2 mV, respectively.

Conclusion: BBD provided optimal formula composition for SNEDDS for obtaining desirable drug loading, emulsion droplet size, and zeta potential.

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Published

27-07-2018

How to Cite

Kumar, B., V. Garg, A. Singh, N. K. Pandey, S. Singh, S. Panchal, I. Melkani, R. Raji, M. Axel, S. Mohanta, J. Jyoti, S. Som, M. Gulati, A. Bhatia, P. T, and S. K. Singh. “INVESTIGATION AND OPTIMIZATION OF FORMULATION PARAMETERS FOR SELFNANOEMULSIFYING DELIVERY SYSTEM OF TWO LIPOPHILIC AND GASTROINTESTINAL LABILE DRUGS USING BOX-BEHNKEN DESIGN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 14, July 2018, pp. 12-18, doi:10.22159/ajpcr.2018.v11s2.28585.

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