EFFECT OF STREBLUS ASPER LEAVES ON LOCOMOTION, ANXIETY AND COGNITION IN RATS

  • SACHIN NEEKHRA Department of Pharmacology, College of Pharmacy, SR Group of Institutions, Jhansi, Uttar Pradesh, India.
  • HIMANI AWASTHI Department of Pharmacology, Amity Institutes of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India.
  • DCP SINGH Department of Pharmaceutical chemistry, HIMT College of Pharmacy, Greater Noida.

Abstract

Objective: The current study deals with the evaluation of neuropharmacological activities of hydroalcoholic extract of the plant Streblus asper.


Methods: Hydroalcoholic extract of S. asper leaves was administered to animals at the dose of 200 and 400 mg/kg p.o., respectively. The neuropharmacological activities, namely, anxiolytic, muscle-relaxant, nootropic, and locomotor activities of hydroalcoholic extract of S. asper leaves were evaluated. The antioxidant activity of the hydroalcoholic extract of S. asper leaves was also investigated.


Results: The dose 400 mg/kg p.o. of hydroalcoholic extract indicated significant variation with control group on neuropharmacological activity, especially nootropic and locomotion, whereas the mentioned dose did not show a significant effect on anxiolytic and muscle-relaxant activities. Percentage scavenging activities and inhibition concentration (IC50) were reported as 63.132 at 100 μg/ml and 35.33, respectively.


Conclusion: It was found that hydroalcoholic extract of S. asper leaves can treat central nervous system disorders caused by oxidative stress.

Keywords: Neuropharmacological, Antioxidant, Streblus asper, Nootropic activity, Locomotion

References

1. Mukherjee P, Roy U. Neuropharmacological profile of an herbal medicine formulation ‘Trasina’ with special reference to antistress activity. Indian J Med Res 1990;84:227-2.
2. Sen P, Mediratta PK, Ray A. Effects of Azadirachta indica A Juss on some biochemical, immunological and visceral parameters in normal and stressed rats. Indian J Exp Biol 1992;30:1170-5.
3. Basuri TS. Analgesic activity of stem bark extracts of Sterblus asper. Int J Pharm Pharm Sci 2011;3:219-20.
4. Li C, Huang C, Lu T, Wu L, Deng S, Yang R, Li J. Tandem mass spectrometric fragmentation behavior of lignans, flavonoids and triterpenoids in Streblus asper. Rapid Commun Mass Sp 2014;28:2363 70.
5. Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2000;55:481-504.
6. Paladini AC, Marder M, Viola H, Wolfman C, Wasowski C, Medina JH. Flavonoids and the central nervous system: From forgotten factors to potent anxiolytic compounds. J Pharm Pharm 1999;51:519-6.
7. Hernandez EA, Eva-gonzalez M, Anna LM, Moreno J, Kite G, Terrazas T, et al. HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. Mexicana. J Ethnopharm 2010;217:91-7.
8. Alamgir AN, Rahman M, Rahman A. Phytochemical characteristics, antimitotic, cytotoxic and antitumor activities of bark extract of Streblus asper lour. Bangladesh J Bot 2013;42:17-2.
9. Singsai K, Akaravichien T, Kukongviriyapan V, Jintana S. Protective effects of Streblus asper leaf extract on H2O2-induced ROS in SK-N-SH cells and MPTP-induced parkinson’s disease-like symptoms in C57BL/6 mouse. Evid Based Complementary Altern Med 2015;1:1-6.
10. Karan SK, Mondal A, Mishra SK, Pal DK, Rout KK. Anti-diabetic effect of Streblus asper in streptozotocin-induced diabetic rats. Pharm Biol 2013;51:369-5.
11. Sripanidkulchai B, Junlatat J, Wara NA, Hormdee D. Anti-inflammatory effect of Streblus asper leaf extract in rats and its modulation on inflammation-associated genes expression in RAW264.7 macrophage cells. J Ethnopharm 2009;124:566-70.
12. Nazneen P, Singhal KC, Khan NU, Singhal P. Potential antifilarial activity of Streblus asper against Setaria cervi (Nematoda: Filarioidea). Indian J Pharm 1989;21:16-21.
13. Hong C, Li J, Wu Q, Niu XT, Tang MT, Guan XL, et al. Anti-HBV activities of Streblus asper and constituents of its roots. Fitoterapia 2012;83:643-9.
14. Vishnoi NK. Advanced Practical Organic Chemistry. 2nd ed. New Delhi: Vikas Publishing House; 2007.
15. Raghbir CG, Sharma V, Sharma N, Kumar N, Singh B. In vitro antioxidant activity from leaves of Oroxylum indicum (L.) Vent. - A North Indian highly threatened and vulnerable medicinal plant. J Pharm Res 2008;1:65-72.
16. Irwin S. Drug screening and evaluative procedures. Science 1962;136 Suppl 3511:123-8.
17. Rani IV, Kiranmai G, Pulla RP. Pharmacological evaluation of antianxiety activity of Desmostachya bipinnata leaves in animal models. Int J Curr Pharm Res 2017;9:152-4.
18. Kulkarni SK, Joseph P. Psychopharmacological profile of siotone granules, a herbal preparation. Indian Drugs 1997;35:536-45.
19. Fancy FA, Shahriar M, Islam MD, Bhuiyan MA. In-vivo anti-pyretic, anti-nociceptive, neuropharmacological activities and acute toxicity investigations of Blumea lacera. Int J Pharm Pharm Sci 2015;7:472-7.
20. Sharma DNK, Khosa RL, Chansauria JP, Sahai M. Antistress activity of Tinospora cordfolia and Centella asiutica extracts. Phytother Res 1996;10:181-3.
21. Cheng WW, Lin CT, Chu FH, Chang ST, Wang SY. Neuropharmacological activities of phytoncide released from Cryptomeria japonica. J Wood Sci 2009;55:27-31.
22. Dhingra D, Parle M, Kulkarni SK. Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharm 2004;91:361-5.
23. Itoh J, Nabeshima T, and Kameyama T. Utility of an elevated plus-maze for the evaluation of memory in mice: Effects of nootropics, scopolamine and electro-convulsive shock. Psychopharmacology 1990;101 Suppl 1:27-33.
24. Hollander E, Mohs RC, Davis KS. Cholinergic approaches to the treatment of Alzheimer’s disease. Br Med Bull 1986;42:97-100.
25. Ogren SO. Biology of Serotonergic Transmission. Chichester: John Wiley and Sons; 1982. p. 317-34.
26. Mrugnandam AV, Kumar V, Bhattacharya SK. Status report on neuropharmacology. Indian J Pharm 2000;32:119-33.
27. Iyer MR, Pal SC, Kasture VS, Kasture SB. Effect of Lawsonia inermis on memory and behavior mediated via monoamine neurotransmitters. Indian J Pharm 1998;30:181-5.
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NEEKHRA, S., H. AWASTHI, and D. SINGH. “EFFECT OF STREBLUS ASPER LEAVES ON LOCOMOTION, ANXIETY AND COGNITION IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 98-01, https://innovareacademics.in/journals/index.php/ajpcr/article/view/28842.
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