• SACHIN NEEKHRA Department of Pharmacology, College of Pharmacy, SR Group of Institutions, Jhansi, Uttar Pradesh, India.
  • HIMANI AWASTHI Department of Pharmacology, Amity Institutes of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India.
  • DCP SINGH Department of Pharmaceutical chemistry, HIMT College of Pharmacy, Greater Noida.


Objective: The current study deals with the evaluation of neuropharmacological activities of hydroalcoholic extract of the plant Streblus asper.

Methods: Hydroalcoholic extract of S. asper leaves was administered to animals at the dose of 200 and 400 mg/kg p.o., respectively. The neuropharmacological activities, namely, anxiolytic, muscle-relaxant, nootropic, and locomotor activities of hydroalcoholic extract of S. asper leaves were evaluated. The antioxidant activity of the hydroalcoholic extract of S. asper leaves was also investigated.

Results: The dose 400 mg/kg p.o. of hydroalcoholic extract indicated significant variation with control group on neuropharmacological activity, especially nootropic and locomotion, whereas the mentioned dose did not show a significant effect on anxiolytic and muscle-relaxant activities. Percentage scavenging activities and inhibition concentration (IC50) were reported as 63.132 at 100 μg/ml and 35.33, respectively.

Conclusion: It was found that hydroalcoholic extract of S. asper leaves can treat central nervous system disorders caused by oxidative stress.

Keywords: Neuropharmacological, Antioxidant, Streblus asper, Nootropic activity, Locomotion


1. Mukherjee P, Roy U. Neuropharmacological profile of an herbal medicine formulation ‘Trasina’ with special reference to antistress activity. Indian J Med Res 1990;84:227-2.
2. Sen P, Mediratta PK, Ray A. Effects of Azadirachta indica A Juss on some biochemical, immunological and visceral parameters in normal and stressed rats. Indian J Exp Biol 1992;30:1170-5.
3. Basuri TS. Analgesic activity of stem bark extracts of Sterblus asper. Int J Pharm Pharm Sci 2011;3:219-20.
4. Li C, Huang C, Lu T, Wu L, Deng S, Yang R, Li J. Tandem mass spectrometric fragmentation behavior of lignans, flavonoids and triterpenoids in Streblus asper. Rapid Commun Mass Sp 2014;28:2363 70.
5. Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2000;55:481-504.
6. Paladini AC, Marder M, Viola H, Wolfman C, Wasowski C, Medina JH. Flavonoids and the central nervous system: From forgotten factors to potent anxiolytic compounds. J Pharm Pharm 1999;51:519-6.
7. Hernandez EA, Eva-gonzalez M, Anna LM, Moreno J, Kite G, Terrazas T, et al. HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. Mexicana. J Ethnopharm 2010;217:91-7.
8. Alamgir AN, Rahman M, Rahman A. Phytochemical characteristics, antimitotic, cytotoxic and antitumor activities of bark extract of Streblus asper lour. Bangladesh J Bot 2013;42:17-2.
9. Singsai K, Akaravichien T, Kukongviriyapan V, Jintana S. Protective effects of Streblus asper leaf extract on H2O2-induced ROS in SK-N-SH cells and MPTP-induced parkinson’s disease-like symptoms in C57BL/6 mouse. Evid Based Complementary Altern Med 2015;1:1-6.
10. Karan SK, Mondal A, Mishra SK, Pal DK, Rout KK. Anti-diabetic effect of Streblus asper in streptozotocin-induced diabetic rats. Pharm Biol 2013;51:369-5.
11. Sripanidkulchai B, Junlatat J, Wara NA, Hormdee D. Anti-inflammatory effect of Streblus asper leaf extract in rats and its modulation on inflammation-associated genes expression in RAW264.7 macrophage cells. J Ethnopharm 2009;124:566-70.
12. Nazneen P, Singhal KC, Khan NU, Singhal P. Potential antifilarial activity of Streblus asper against Setaria cervi (Nematoda: Filarioidea). Indian J Pharm 1989;21:16-21.
13. Hong C, Li J, Wu Q, Niu XT, Tang MT, Guan XL, et al. Anti-HBV activities of Streblus asper and constituents of its roots. Fitoterapia 2012;83:643-9.
14. Vishnoi NK. Advanced Practical Organic Chemistry. 2nd ed. New Delhi: Vikas Publishing House; 2007.
15. Raghbir CG, Sharma V, Sharma N, Kumar N, Singh B. In vitro antioxidant activity from leaves of Oroxylum indicum (L.) Vent. - A North Indian highly threatened and vulnerable medicinal plant. J Pharm Res 2008;1:65-72.
16. Irwin S. Drug screening and evaluative procedures. Science 1962;136 Suppl 3511:123-8.
17. Rani IV, Kiranmai G, Pulla RP. Pharmacological evaluation of antianxiety activity of Desmostachya bipinnata leaves in animal models. Int J Curr Pharm Res 2017;9:152-4.
18. Kulkarni SK, Joseph P. Psychopharmacological profile of siotone granules, a herbal preparation. Indian Drugs 1997;35:536-45.
19. Fancy FA, Shahriar M, Islam MD, Bhuiyan MA. In-vivo anti-pyretic, anti-nociceptive, neuropharmacological activities and acute toxicity investigations of Blumea lacera. Int J Pharm Pharm Sci 2015;7:472-7.
20. Sharma DNK, Khosa RL, Chansauria JP, Sahai M. Antistress activity of Tinospora cordfolia and Centella asiutica extracts. Phytother Res 1996;10:181-3.
21. Cheng WW, Lin CT, Chu FH, Chang ST, Wang SY. Neuropharmacological activities of phytoncide released from Cryptomeria japonica. J Wood Sci 2009;55:27-31.
22. Dhingra D, Parle M, Kulkarni SK. Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharm 2004;91:361-5.
23. Itoh J, Nabeshima T, and Kameyama T. Utility of an elevated plus-maze for the evaluation of memory in mice: Effects of nootropics, scopolamine and electro-convulsive shock. Psychopharmacology 1990;101 Suppl 1:27-33.
24. Hollander E, Mohs RC, Davis KS. Cholinergic approaches to the treatment of Alzheimer’s disease. Br Med Bull 1986;42:97-100.
25. Ogren SO. Biology of Serotonergic Transmission. Chichester: John Wiley and Sons; 1982. p. 317-34.
26. Mrugnandam AV, Kumar V, Bhattacharya SK. Status report on neuropharmacology. Indian J Pharm 2000;32:119-33.
27. Iyer MR, Pal SC, Kasture VS, Kasture SB. Effect of Lawsonia inermis on memory and behavior mediated via monoamine neurotransmitters. Indian J Pharm 1998;30:181-5.
114 Views | 132 Downloads
How to Cite
NEEKHRA, S., H. AWASTHI, and D. SINGH. “EFFECT OF STREBLUS ASPER LEAVES ON LOCOMOTION, ANXIETY AND COGNITION IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 98-101, doi:10.22159/ajpcr.2019.v12i2.28842.
Original Article(s)