• SACHIN NEEKHRA Department of Pharmacology, College of Pharmacy, SR Group of Institutions, Jhansi, Uttar Pradesh, India.
  • HIMANI AWASTHI Department of Pharmacology, Amity Institutes of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India.
  • DCP SINGH Department of Pharmaceutical chemistry, HIMT College of Pharmacy, Greater Noida.


Objective: The current study deals with the evaluation of neuropharmacological activities of hydroalcoholic extract of the plant Streblus asper.

Methods: Hydroalcoholic extract of S. asper leaves was administered to animals at the dose of 200 and 400 mg/kg p.o., respectively. The neuropharmacological activities, namely, anxiolytic, muscle-relaxant, nootropic, and locomotor activities of hydroalcoholic extract of S. asper leaves were evaluated. The antioxidant activity of the hydroalcoholic extract of S. asper leaves was also investigated.

Results: The dose 400 mg/kg p.o. of hydroalcoholic extract indicated significant variation with control group on neuropharmacological activity, especially nootropic and locomotion, whereas the mentioned dose did not show a significant effect on anxiolytic and muscle-relaxant activities. Percentage scavenging activities and inhibition concentration (IC50) were reported as 63.132 at 100 μg/ml and 35.33, respectively.

Conclusion: It was found that hydroalcoholic extract of S. asper leaves can treat central nervous system disorders caused by oxidative stress.

Keywords: Neuropharmacological, Antioxidant, Streblus asper, Nootropic activity, Locomotion


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How to Cite
NEEKHRA, S., H. AWASTHI, and D. SINGH. “EFFECT OF STREBLUS ASPER LEAVES ON LOCOMOTION, ANXIETY AND COGNITION IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 98-01, https://innovareacademics.in/journals/index.php/ajpcr/article/view/28842.
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