IN VITRO ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF SEEDPOD AND QUERCETIN OF NELUMBO NUCIFERA GAERTN

  • Ruvanthika Pn Department of Physiology, Tagore Medical College and Hospitals, Chennai - 600127 (PhD program in Bharath University, Chennai, 600073, India) Affiliated to TN Dr. MGR Medical University, Guindy, Chennai - 600 032, Tamil Nadu, India.
  • Manikandan S Department of Physiology, Tagore Medical College and Hospitals, Affiliated to TN Dr. MGR Medical University, Guindy, Chennai - 600 032, Tamil Nadu, India.

Abstract

Objective: The objective of the study was to evaluate whether ethanolic extracts of Nelumbo nucifera (EENN) seedpod and quercetin (active component of NN) possess antibacterial proprieties against Gram (-) bacteria such as Escherichia coli and Pseudomonas aeruginosa and Gram (+) bacteria such as Staphylococcus aureus.

Methods: Antibacterial activities of EENN seedpod and quercetin were investigated using disc diffusion method, minimum inhibitory concentration against E. coli and P. aeruginosa and Gram (+) bacteria such as S. aureus.

Results: The antibacterial activity of both EENN seedpod and quercetin was found to be increased in dose-dependent manner. The maximum zone of inhibition was exhibited by both EENN seedpod and quercetin against E. coli (14 mm and 15 mm) and P. aeruginosa (13 mm and 15 mm). Gram-negative bacteria were more susceptible to the EENN seedpod extract and quercetin than Gram-positive bacteria.

Conclusion: The results of the present study suggested that the effect of EENN seedpod and quercetin against the tested bacteria in vitro may contribute to the in vivo activities of the EENN seedpod and quercetin.

Keywords: Nelumbo nucifera, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa.

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How to Cite
Pn, R., and M. S. “IN VITRO ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF SEEDPOD AND QUERCETIN OF NELUMBO NUCIFERA GAERTN”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 1, Jan. 2019, pp. 164-7, doi:10.22159/ajpcr.2019.v12i1.28915.
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