THE STATUS OF HAIR MINERALS IN CHRONIC FATIGUE AND DEPRESSED WOMEN
Objective: Chronic fatigue and depression are common problems in primary care. The status of micronutrients may be related to two conditions. The present study aimed to identify the association of minerals with chronic fatigue and depression.
Methods: We conducted a cross-sectional study using medical records of 97 female patients aged 20â€“64 years old who visited the integrated medical center of a university hospital in Gyeongju, South Korea, from 2013 to 2016. Collected information comprised their scores for the fatigue severity scale, beck depression inventory, and concentrations of mineral in hair samples.
Results: The subjects were classified into three groups according to their depression and fatigue scores: 21 patients (21.6%) were free of fatigue and depression, 55 (56.8%)experienced fatigue without depression, and 21 (21.6%) experienced fatigue with depression. The potassium (K) concentration in hair significantly decreased in the groups of fatigue or fatigue with depression compared to the group with free of fatigue and depression (p=0.042). The trend of sodium (Na), K concentration, and Na/magnesium (Mg) ratios in hair gradually decreased with fatigue and depression (p for trend=0.027, 0.037, and 0.03).
Conclusion: Chronic fatigue and depression in women are associated with the concentrations of hair minerals, especially Na, K, and Na/Mg ratios.
2. Manu P, Matthews DA, Lane TJ. The mental health of patients with a chief complaint of chronic fatigue. A prospective evaluation and follow-up. Arch Intern Med 1988;148:2213-7.
3. De Wester JN. Recognizing and treating the patient with somatic manifestations of depression. J Fam Pract 1996;43 Suppl 6:3-15.
4. Vormann J. Magnesium: Nutrition and metabolism. Mol Aspects Med 2003;24:27-37.
5. Myhill S, Booth NE, McLaren-Howard J. Targeting mitochondrial dysfunction in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs)-a clinical audit. Int J Clin Exp Med 2013;6:1 15.
6. Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, NÃ¨ve J, De Leeuw I, et al. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: Effects of supplementation with magnesium. J Am Coll Nutr 2000;19:374-82.
7. Kaner G, Soylu M, YÃ¼ksel N, InanÃ§ N, Ongan D, BaÅŸmÄ±sÄ±rlÄ± E, et al. Evaluation of nutritional status of patients with depression. Biomed Res Int 2015;2015:521481.
8. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989;46:1121-3.
9. Kim S, Bae WK, Kim JY, Jang M, Kim JH, Noh HH, et al. Validation of the Korean version of schedule of fatigue and anergia: General physician questionnaire. J Korean Med Sci 2016;31:159-63.
10. Chung KI, Song CH. Clinical usefulness of fatigue severity scale for patients with fatigue, and anxiety or depression. Korean J Psychosom Med 2001;9:164-73.
11. Lee EJ, Kim JB, Shin IH, Lim KH, Lee SH, Cho GA, et al. Current use of depression rating scales in mental health setting. Psychiatry Investig 2010;7:170-6.
12. Lee MK, Lee YH, Park SH, Sohn CH, Jung YJ, Hong SK, et al. A standardization study of beck depression inventory (I): Korean version (K-BDI): Reliability land factor analysis. Korean J Psychopathol 1995;4:77-95.
13. Trace Elements, Inc. Quality Assurance/Quality Control (QA/QC), Texas; 2018. Available from: http://www.traceelements.com/LabServices/QualityAssurance.aspx.
14. Hong SR, Lee SM, Lim NR, Chung HW, Ahn HS. Association between hair mineral and age, BMI and nutrient intakes among Korean female adults. Nutr Res Pract 2009;3:212-9.
15. Sekhri K, Kaur K. Public knowledge, use and attitude toward multivitamin supplementation: A cross-sectional study among general public. Int J Appl Basic Med Res 2014;4:77-80.
16. Long SJ, Benton D. Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: A meta-analysis. Psychosom Med 2013;75:144-53.
17. Burton RF, Hinton JW, Neilson E, Beastall G. Concentrations of sodium, potassium and cortisol in saliva, and self-reported chronic work stress factors. Biol Psychol 1996;42:425-38.
18. Rowe PC, Bou-Holaigah I, Kan JS, Calkins H. Is neurally mediated hypotension an unrecognised cause of chronic fatigue? Lancet 1995;345:623-4.
19. Grippo AJ, Moffitt JA, Beltz TG, Johnson AK. Reduced hedonic behavior and altered cardiovascular function induced by mild sodium depletion in rats. Behav Neurosci 2006;120:1133-43.
20. Goldstein P, Leshem M. Dietary sodium, added salt, and serum sodium associations with growth and depression in the U.S. general population. Appetite 2014;79:83-90.
21. Prejbisz A, WarchoÅ‚-CeliÅ„ska E, Lenders JW, Januszewicz A. Cardiovascular risk in primary hyperaldosteronism. Horm Metab Res 2015;47:973-80.
22. Murck H, Held K, Ziegenbein M, KÃ¼nzel H, Koch K, Steiger A. The renin-angiotensin-aldosterone system in patients with depression compared to controls--a sleep endocrine study. BMC Psychiatry 2003;3:15.
23. Hallberg L, Westrin A, Isaksson A, Janelidze S, TrÃ¤skman-Bendz L, Brundin L. Decreased aldosterone in the plasma of suicide attempters with major depressive disorder. Psychiatry Res 2010;187:135-9.
24. Flatman PW. Mechanism of magnesium transport. Annu Rev Physiol 1991;53:259-71.
25. Kurajoh M, Ohsugi K, Kakutani-Hatayama M, Shoji T, Koyama H. Hypokalemia associated with pseudo-Cushingâ€™s syndrome and magnesium deficiency induced by chronic alcohol abuse. CEN Case Rep 2018;7:148-52.
26. Cinar V, Mogulkoc R, Baltaci AK, Polat Y. Adrenocorticotropic hormone and cortisol levels in athletes and sedentary subjects at rest and exhaustion: Effects of magnesium supplementation. Biol Trace Elem Res 2008;121:215-20.
27. Rimes KA, Papadopoulos AS, Cleare AJ, Chalder T. Cortisol output in adolescents with chronic fatigue syndrome: Pilot study on the comparison with healthy adolescents and change after cognitive behavioural guided self-help treatment. J Psychosom Res 2014;77:409 14.
28. Grynderup MB, Kolstad HA, Mikkelsen S, Andersen JH, Bonde JP, ButtenschÃ¸n HN, et al. A two-year follow-up study of salivary cortisol concentration and the risk of depression. Psychoneuroendocrinology 2013;38:2042-50.
29. Vanaelst B, Michels N, Huybrechts I, Clays E, FlÃ³rez MR, Balcaen L, et al. Cross-sectional relationship between chronic stress and mineral concentrations in hair of elementary school girls. Biol Trace Elem Res 2013;153:41-9.
30. Gogoi P, Kalita J.C. Mineral content of some edible medicinally important leafy vegetables of Kamrup district of Assam, India. Int J Pharm Pharm Sci 2014;6:404-6.
31. Prashanth Kumar GM, Chikkapaih L, Nagayya S. Nutritional analysis of edible wild plants used by Hakki Pikki tribes of Hassan district, Karnataka, India. Int J Pharm Pharm Sci 2016;8:390-3.
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